ArticlePloS one2018
Gender as an independent prognostic factor in small-cell lung cancer: Inha Lung Cancer Cohort study using propensity score matching.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Prognostic relevance of geriatric nutritional risk index and the prognostic nutritional index in geriatric extensive stage small cell lung cancer.Scientific reports · 2025Article
- Efficacy of PD-(L)1 inhibitors plus anlotinib in the second-line treatment of extensive-stage small cell lung cancer.BMC cancer · 2025Article
- Real-world analysis of immunochemotherapy in recurrent small-cell lung cancer: opportunities for second-line approaches.Frontiers in pharmacology · 2025Article
- Tarlatamab and the Future of Immunotherapy: A New Approach to Small Cell Lung Cancer.Current therapeutic research, clinical and experimental · 2025Article
- Development of a nomogram for overall survival prediction in primary upper lobe lung cancer patients: A SEER population-based analysis.PloS one · 2025Article
- Common laboratory parameters as predictors of prognosis in primary lung cancer.Frontiers in oncology · 2025Article
- Nomogram predicting overall and cancer specific prognosis for poorly differentiated lung adenocarcinoma after resection based on SEER cohort analysis.Scientific reports · 2024Article
- Differential Effect of Consolidative Thoracic Radiation Therapy in Extensive-Stage Small Cell Lung Cancer Based on Sex.Advances in radiation oncology · 2024Article
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- Trends in Epidemiology and Outcome of Small Cell Lung Cancer over 10 Years at Tertiary Cancer Care Center in Iran.Tanaffos · 2023Article
- Serum cytokine levels and other associated factors as possible immunotherapeutic targets and prognostic indicators for lung cancer.Frontiers in oncology · 2023Review
- Clinical and prognostic implications of CD47 and PD-L1 expression in surgically resected small-cell lung cancer.ESMO open · 2022Article
- Value of plasma vitamin D level and nomogram model for predicting the prognosis of patients with small cell lung cancer treated with platinum plus etoposide as first-line chemotherapy.American journal of translational research · 2022Article
- The predictive and prognostic value of sex in localized colorectal cancer: a SEER-based analysis.Translational cancer research · 2021Article
- Prognostic indicators of survival in patients with small-cell lung cancer at a tertiary care center in Lebanon.SAGE open medicine · 2021Article
- Article
- Analysis of systemic inflammatory biomarkers in neuroendocrine carcinomas of the lung: prognostic and predictive significance of NLR, LDH, ALI, and LIPI score.Therapeutic advances in medical oncology · 2020Article
- Proteomic analysis of sex differences in hyperoxic lung injury in neonatal mice.International journal of medical sciences · 2020Article
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5 authors.
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Abstract
introductionThe prognostic relevance of gender is undetermined in patients with small-cell lung cancer (SCLC). Therefore, we investigated whether gender is a prognostic factor in a SCLC cohort after controlling for confounding factors. MATERIALS AND
methodsFifteen prognostic factors were classified into four groups (patient, stage migration, tumor, and treatment). The prognostic relevance of gender was evaluated using propensity score matching, Cox proportional hazards regression, and stepwise fashion adjustments.
resultsOf 591 patients with SCLC, 88 were women (14.9%). Women were more likely than men to have no history of smoking (48.9% vs. 2.0%, P < 0.001) and limited disease (48.9% vs. 37.8%, P = 0.050). Women had less progressive disease in M stage than men (52.3% vs. 62.8%, P = 0.031). Women had better survival than men in the entire cohort (median survival times [MSTs] and 95% confidence intervals [CIs]: 9.7 months and 7.8-11.6 for women, 8.0 months and 7.0-8.9 for men, log-rank P = 0.034) and in the matched cohort (MSTs and 95% CIs: 8.8 months and 5.8-11.8 for women, 5.9 months and 4.5-7.4 for men, log-rank P = 0.013). Female gender was a prognostic factor predicting better survival, even after stepwise and full adjustment with all prognostic variables (adjusted hazard ratios and 95% CIs: 0.51 and 0.34-0.77, P = 0.001 for entire cohort, 0.42 and 0.24-0.75, P = 0.003 for matched cohort).
conclusionsOur results confirmed that gender is an independent prognostic factor in patients with SCLC.
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