Evidence map›Paper›PMID 30532991›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2019

Transgene-associated human growth hormone expression in pancreatic β-cells impairs identification of sex-based gene expression differences.

Jennifer S Stancill, Anna B Osipovich, Jean-Philippe Cartailler, Mark A Magnuson

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

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  5. Comprehensive analysis of EML2 as a prognostic biomarker in colon cancer.International journal of clinical and experimental pathology · 2024
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  15. Peroxiredoxin 1 plays a primary role in protecting pancreatic β-cells from hydrogen peroxide and peroxynitrite.American journal of physiology. Regulatory, integrative and comparative physiology · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jennifer S StancillDepartment of Cell and Developmental Biology, Vanderbilt University , Nashville, Tennessee.
Anna B OsipovichDepartment of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee.
Jean-Philippe CartaillerCenter for Stem Cell Biology, Vanderbilt University , Nashville, Tennessee.
Mark A MagnusonDepartment of Cell and Developmental Biology, Vanderbilt University , Nashville, Tennessee.ORCID 0000-0002-8824-6499
Vanderbilt University · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Coordinating Center for Beta Cell Biology ConsortiumU01DK072473 · NIDDK · VANDERBILT UNIVERSITY · PI MAGNUSON, MARK A · 2005 to 2014
$61.0M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALVIN C POWERS · 2012 to 2026
$29.3M
Genetic control of pancreatic endocrine cell developmentU01DK089523 · NIDDK · VANDERBILT UNIVERSITY · PI MAGNUSON, MARK A · 2010 to 2014
$5.3M
Training in Signature Transdisciplinary Cardiovascular SciencesT32HL134643 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Justin L Grobe, Jacquelyn P Kulinski · 2017 to 2026
$4.2M
High-Performance Computer Cluster for Biomedical ResearchS10OD023680 · OD · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2017 to 2017
$587k
NCI NIH HHS P30 CA068485NHLBI NIH HHS T32 HL134643NIDDK NIH HHS P30 DK020593NIDDK NIH HHS U01 DK072473NIDDK NIH HHS U01 DK089523NIH HHS S10 OD023680
6 · The paper itself

Abstract

Fluorescent protein reporter genes are widely used to identify and sort murine pancreatic β-cells. In this study, we compared use of the MIP-GFP transgene, which exhibits aberrant expression of human growth hormone (hGH), with a newly derived Ins2

Indexed as

AnimalsFemaleGene ExpressionGenes, ReporterGreen Fluorescent ProteinsHomeobox Protein Nkx-2.2Homeodomain ProteinsHuman Growth HormoneHumansInsulinInsulin-Secreting CellsMaleMiceMice, TransgenicNuclear ProteinsPromoter Regions, GeneticGreen Fluorescent ProteinsHomeobox Protein Nkx-2.2Homeodomain ProteinsHuman Growth HormoneIns1 protein, mouseIns2 protein, mouseInsulinNKX2-2 protein, humanNkx2-2 protein, mouseNuclear ProteinsRNA, MessengerTranscription Factorsgene expressiongrowth hormonepancreatic β-cellsRNA-Seqsex

Identifiers

PMID30532991
PMCPMC6397359
OpenAlexW2905309048

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.