Evidence map›Paper›PMID 30532779›Full record

ArticleInternational journal of endocrinology2018

Safety and Efficacy of Low-Level Laser Therapy in Autoimmune Thyroiditis: Long-Term Follow-Up Study.

Danilo Bianchini Höfling, Maria Cristina Chavantes, Carlos Alberto Buchpiguel, Giovanni Guido Cerri, Suemi Marui, Paulo Campos Carneiro, Maria Cristina Chammas

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02240563 (Long-term Follow-up After Treatment of Chronic Autoimmune Thyroiditis With Low Level Laser), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02240563 nacompletednot on this map

Long-term Follow-up After Treatment of Chronic Autoimmune Thyroiditis With Low Level Laser

TypeinterventionalSponsorUniversity of Sao Paulo General HospitalRan2014 to 2016Enrolled43ConditionsAutoimmune ThyroiditisArmsLow-level laser therapy, Non laser ordinary red light
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Low-Level Laser Therapy in the Treatment of Autoimmune Thyroiditis.Journal of lasers in medical sciences · 2022
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Danilo Bianchini HöflingUltrasound Unit, Department of Radiology, University of Sao Paulo Medical School, Hospital das Clínicas, 05403-000 São Paulo, SP, Brazil.ORCID 0000-0002-5636-663X
Maria Cristina ChavantesUniversidade Nove de Julho, Post-Graduation, 01504-001 São Paulo, SP, Brazil.
Carlos Alberto BuchpiguelRadiology Institute (InRad); Department of Radiology, University of Sao Paulo Medical School, Hospital das Clínicas, 05403-000 São Paulo, SP, Brazil.
Giovanni Guido CerriRadiology Institute (InRad); Department of Radiology, University of Sao Paulo Medical School, Hospital das Clínicas, 05403-000 São Paulo, SP, Brazil.
Suemi MaruiThyroid Unit, Department of Endocrinology and Metabolism, University of Sao Paulo Medical School, Hospital das Clínicas, 05403-000 São Paulo, Brazil.ORCID 0000-0002-0744-3942
Paulo Campos CarneiroDepartment of Pathology, University of Sao Paulo Medical School, Hospital das Clínicas, 05403-000 São Paulo, Brazil.
Maria Cristina ChammasUltrasound Unit, Department of Radiology, University of Sao Paulo Medical School, Hospital das Clínicas, 05403-000 São Paulo, SP, Brazil.ORCID 0000-0001-7041-3079
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRUniversidade Nove de Julho · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionA randomized clinical trial (RCT) was performed to evaluate the efficacy of low-level laser therapy (LLLT) for hypothyroidism induced by chronic autoimmune thyroiditis (CAT).

objectiveThe objective was to assess the safety and actions of LLLT 6 years after completion of the RCT. MATERIALS AND

methodsForty-three participants were invited to participate in this study 6 years after completion of the RCT. Twenty-five were subjected to LLLT (group L), and 18 were subjected to placebo (group P). Primary outcome measure: frequency of thyroid nodules, which were subjected to fine-needle aspiration biopsy. Secondary outcome measures: dose of levothyroxine required to treat hypothyroidism, thyroid peroxidase antibodies (anti-TPO), and anti-thyroglobulin antibodies (anti-Tg).

resultsIn group L, a nodule was observed in three patients, who all had a Bethesda II classification. In group P, a nodule was also observed in three patients, with two classified as Bethesda II and one as Bethesda III. The levothyroxine dose required by group L was significantly lower than that required by group P (

conclusionLLLT, by the methods described, has been shown to be safe for the treatment of hypothyroidism resulting from CAT. This trial is registered with ClinicalTrials.gov Identifier: NCT02240563.

Identifiers

PMID30532779
PMCPMC6247385
OpenAlexW2899490494

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.