ArticleFrontiers in aging neuroscience2018
Dynamic Functional Connectivity and Symptoms of Parkinson's Disease: A Resting-State fMRI Study.
Article in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Mirror therapy reduces excessive variability of motor network in stroke patients: a randomized controlled trial.European journal of physical and rehabilitation medicine · 2025Trial
- Altered Inter-Network Functional Integration Underlies Speech Impairment in Parkinson's Disease: A Resting-State fMRI Analysis.Brain and behavior · 2026Article
- Neuroimaging of the monoaminergic system in Parkinson's disease: A narrative review.Neuroimage. Reports · 2026Review
- Neuromodulation-induced normalization of cortical metastable dynamics signatures in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Dynamic thalamocortical functional connectivity disruptions in Parkinson's disease with probable REM sleep behavior disorder.Scientific reports · 2026Article
- Linking Connectivity Dynamics to Symptom Severity and Cognitive Abilities in Children with Autism Spectrum Disorder: An FNIRS Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Altered dynamic functional connectivity and reduced higher order information interaction in Parkinson's patients with hyposmia.NPJ systems biology and applications · 2025Article
- Common and unique network basis for externally and internally driven flexibility in cognition: From a developmental perspective.Developmental cognitive neuroscience · 2025Article
- Changes in brain functional connectivity between on and off states and their relationship with cognitive impairment in Parkinson's disease.Scientific reports · 2024Article
- Neonatal brain dynamic functional connectivity in term and preterm infants and its association with early childhood neurodevelopment.Nature communications · 2024Article
- Interaction of 5-HTTLPR and SLE disease status on resting-state brain function.Arthritis research & therapy · 2024Article
- Article
- Differences and Changes in Cerebellar Functional Connectivity of Parkinson's Patients with Visual Hallucinations.Brain sciences · 2023Article
- Social and non-social working memory in neurodegeneration.Neurobiology of disease · 2023Article
- Temporal Dynamics of Resting-state Functional Networks and Cognitive Functioning following Systemic Treatment for Breast Cancer.Brain imaging and behavior · 2022Article
- Light sedation with short habituation time for large-scale functional magnetic resonance imaging studies in rats.NMR in biomedicine · 2022Article
- Divergent time-varying connectivity of thalamic sub-regions characterizes clinical phenotypes and cognitive status in multiple sclerosis.Molecular psychiatry · 2022Article
- Impaired Brain Information Transmission Efficiency and Flexibility in Parkinson's Disease and Rapid Eye Movement Sleep Behavior Disorder: Evidence from Functional Connectivity and Functional Dynamics.Parkinson's disease · 2022Article
- Functional Connectivity of the Brain Across Rodents and Humans.Frontiers in neuroscience · 2022Review
- Treatment Enhances Betweenness Centrality of Fronto-Parietal Network in Parkinson's Patients.Frontiers in computational neuroscience · 2022Article
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5 authors.
Funding
Abstract
Research has shown that dynamic functional connectivity (dFC) in Parkinson's disease (PD) is associated with better attention performance and with motor symptom severity. In the current study, we aimed to investigate dFC of both the default mode network (DMN) and the frontoparietal network (FPN) as neural correlates of cognitive functioning in patients with PD. Additionally, we investigated pain and motor problems as symptoms of PD in relation to dFC. Twenty-four PD patients and 27 healthy controls participated in this study. Memory and executive functioning were assessed with neuropsychological tests. Pain was assessed with the Numeric Rating Scale (NRS); motor symptom severity was assessed with the Unified Parkinson's Disease Rating Scale (UPDRS). All subjects underwent resting-state functional magnetic resonance imaging (fMRI), from which dFC was defined by calculating the variability of functional connectivity over a number of sliding windows within each scan. dFC of both the DMN and FPN with the rest of the brain was calculated. Patients performed worse on tests of visuospatial memory, verbal memory and working memory. No difference existed between groups regarding dFC of the DMN nor the FPN with the rest of the brain. A positive correlation existed between dFC of the DMN and visuospatial memory. Our results suggest that dynamics during the resting state are a neural correlate of visuospatial memory in PD patients. Furthermore, we suggest that brain dynamics of the DMN, as measured with dFC, could be a phenomenon specifically linked to cognitive functioning in PD, but not to other symptoms.
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