Evidence map›Paper›PMID 30532554›Full record

ArticleOncoTargets and therapy2018

Potential role of Toll-like receptor 2 expression and polymorphisms in colon cancer susceptibility in the Saudi Arabian population.

Abdelhabib Semlali, Narasimha Reddy Parine, Nouf S Al-Numair, Mikhlid Almutairi, Yousef M Hawsawi, Abdullah Al Amri, Abdulrahman M Aljebreen, Maha Arafah, Majid A Almadi, Nahla Ali Azzam and 2 more

Open access · goldAbstract read
In one paragraph

Article in OncoTargets and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Variants rs3804099 and rs3804100 in theInternational journal of molecular sciences · 2024
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  16. Prostate cancer and therapeutic challenges.Journal of biological research (Thessalonike, Greece) · 2020
    Review
  17. Article
  18. Article
  19. Characterization and strong risk association ofWorld journal of gastrointestinal oncology · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Abdelhabib SemlaliGroupe de Recherche en Écologie Buccale, Département de stomatologie, Faculté de Médecine Dentaire, Université Laval, Quebec City, QC, Canada, asemlali@ksu.edu.sa.
Narasimha Reddy ParineGenome Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia, asemlali@ksu.edu.sa.
Nouf S Al-NumairDepartment of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
Mikhlid AlmutairiZoology Department, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Yousef M HawsawiDepartment of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
Abdullah Al AmriGenome Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia, asemlali@ksu.edu.sa.
Abdulrahman M AljebreenCollege of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Maha ArafahCollege of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Majid A AlmadiCollege of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Nahla Ali AzzamCollege of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Othman AlharbiCollege of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Mohammad Saud AlanaziGenome Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia, asemlali@ksu.edu.sa.
King Saud University · SAAlfaisal University · SAKing Faisal Specialist Hospital & Research Centre · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInflammation is a fundamental factor that contributes to the development and progression of several types of cancer including colon cancer. Toll-like receptors (

methodsReal-time PCR and immunohistochemistry were used to investigate

resultsWe found that,

conclusionsThere was a significant link between innate immunity deregulation through disruption of the

Indexed as

colon cancergene expressiongenotypinginnate immunitypolymorphismToll-like receptors

Identifiers

PMID30532554
PMCPMC6241690
OpenAlexW2900767667

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.