ArticleInternational journal of chronic obstructive pulmonary disease
Identification of novel candidate genes involved in the progression of emphysema by bioinformatic methods.
Article in International journal of chronic obstructive pulmonary disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Activation of the proton-sensing GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory joint pain.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Peripheral Blood Mononuclear Cell Gene Expression Associated with Pulmonary Microvascular Perfusion: The Multi-Ethnic Study of Atherosclerosis Chronic Obstructive Pulmonary Disease.Annals of the American Thoracic Society · 2024Article
- Computational prognostic evaluation of Alzheimer's drugs from FDA-approved database through structural conformational dynamics and drug repositioning approaches.Scientific reports · 2023Article
- Exploration of glycosyltransferases mutation status in cervical cancer reveals PARP14 as a potential prognostic marker.Glycoconjugate journal · 2023Article
- Dynamic analysis of gene signatures in the progression of COPD.ERJ open research · 2023Article
- Chronic Obstructive Pulmonary Disease Is Associated with Epigenome-Wide Differential Methylation in BAL Lung Cells.American journal of respiratory cell and molecular biology · 2022Article
- Newborn DNA methylation and asthma acquisition across adolescence and early adulthood.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022Article
- Host Factor Interaction Networks Identified by Integrative Bioinformatics Analysis Reveals Therapeutic Implications in COPD Patients With COVID-19.Frontiers in pharmacology · 2021Article
- Aberrant Methylation of Aging-Related Genes in Asthma.Frontiers in molecular biosciences · 2021Article
- Identification of Inflammation-Related Biomarker Lp-PLA2 for Patients With COPD by Comprehensive Analysis.Frontiers in immunology · 2021Article
- STRING data mining of GWAS data in canine hereditary pigment-associated deafness.Veterinary and animal science · 2020Article
- Identification of differentially expressed genes and enriched pathways in lung cancer using bioinformatics analysis.Molecular medicine reports · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBy reanalyzing the gene expression profile GSE76925 in the Gene Expression Omnibus database using bioinformatic methods, we attempted to identify novel candidate genes promoting the development of emphysema in patients with COPD. PATIENTS AND
methodsAccording to the Quantitative CT data in GSE76925, patients were divided into mild emphysema group (%LAA-950<20%, n=12) and severe emphysema group (%LAA-950>50%, n=11). Differentially expressed genes (DEGs) were identified using Agilent GeneSpring GX v11.5 (corrected
resultsAll the patients had COPD with severe airflow limitation (age=62±8, FEV
conclusionCandidate genes such as GPR65, NPSR1, and TP53 may be involved in the progression of emphysema.
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