ArticlePLoS neglected tropical diseases2018
The disabling consequences of Mycetoma.
Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Global sociodemographic, clinical, and epidemiological profiling of patients with mycetoma: A systematic review.PLoS neglected tropical diseases · 2025Pooled it
- Eumycetoma causative agents: A systematic review to inform the World Health Organization priority list of fungal pathogens.Medical mycology · 2024Pooled it
- A balancing act: Navigating the advantages and challenges of pioneering mycetoma treatment in Sudan-A landmark trial by the Mycetoma Research Center.PLoS neglected tropical diseases · 2025Trial
- Contribution of fungal diseases to the U.S. chronic disease burden.Clinical microbiology reviews · 2026Review
- Mycetoma.PLoS neglected tropical diseases · 2026Review
- Mycetoma as a major cause of limb amputation in Northeastern Ethiopia: A facility-based retrospective study.PLoS neglected tropical diseases · 2026Article
- Environmental and structural risk factors for mycetoma in the White Nile State, Sudan: an ethnographic study.International journal for equity in health · 2026Article
- Molecular docking approaches in mycetoma: Toward improved patient management.PLoS neglected tropical diseases · 2026Review
- The contribution of mycetoma grains to suboptimal disease management.Nature communications · 2025Review
- Medical and health students' insights into mycetoma: A survey-based study on knowledge and clinical practices.PLoS neglected tropical diseases · 2025Article
- Kinome analysis of Madurella mycetomatis identified kinases in the cell wall integrity pathway as novel potential therapeutic drug targets in eumycetoma caused by Madurella mycetomatis.PLoS neglected tropical diseases · 2025Article
- Orbital actinomadura madurae actinomycetoma: Case report and literature review.PLoS neglected tropical diseases · 2025Review
- Quality of Life, Disability, and Fungal Neglected Tropical Diseases.Current fungal infection reports · 2025Article
- South-East Asia regional neglected tropical disease framework: improving control of mycetoma, chromoblastomycosis, and sporotrichosis.The Lancet regional health. Southeast Asia · 2025Review
- Mycetoma managment: Therapeutic challenges and the role of pharmacovigilance.PLoS neglected tropical diseases · 2025Review
- Sustained neutrophil infiltration and bacterial grain morphology underlie chronic mycetoma pathology in a murine model.Iranian journal of basic medical sciences · 2025Article
- Towards enhanced control of mycetoma: a roadmap to achieve the UN's sustainable development goals by 2030.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2024Article
- Community-Based Mycetoma Surveillance in Uganda: Identifying Knowledge Gaps and Training of Community Health Workers to Improve Case Detection.PLoS neglected tropical diseases · 2024Article
- A study of case management challenge for black grain eumycetoma during the ongoing war in Sudan.Clinical case reports · 2024Article
- Hope amidst neglect: Mycetoma Research Center, University of Khartoum. A holistic management approach to achieve the United Nations' Sustainable Development Goals.PLoS neglected tropical diseases · 2024Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycetoma is a neglected tropical disease endemic in tropical and subtropical countries, particularly Sudan. The disease is characterised by the triad of painless subcutaneous mass, multiple sinuses and discharge that contain grains. It is a chronic, debilitating disease most commonly affecting the feet or hands and leads to substantial morbidity, loss of function and even amputation. It predominantly affects poor, rural populations and patients typically present late with advanced disease and complications. In this descriptive cross-sectional study, we characterise the disabling consequences of mycetoma. The study included 300 patients; 228 (76%) male and 72 (24%) female with confirmed mycetoma seen at the Mycetoma Research Centre, University of Khartoum, Sudan in the period May 2016 and January 2017. The study design was based upon the International Classification of Functioning, Disability and Health, examining the impact of mycetoma on eight life domains. Our major finding is that mycetoma is a significantly disabling disease. Over 60% of the study population (181 patients) had moderate impairment or difficulty in at least one domain variable. The important disability was mobility impairment and walking difficulty that was reported in 119 patients (39.7%). There was significant pain associated with mycetoma lesions in 103 patients (34%), challenging the traditional view of mycetoma as a painless disease. The economic burden was also found to be substantial, with 126 patients (46.7%) reporting barriers to their ability to sustain themselves. This is the first study evaluating the disabling consequences of mycetoma and shows clear areas for intervention and further research. Options for mitigating social and economic impacts include routine integration of analgesia and physiotherapy into treatment protocols, and adapting educational provision and working practices based on disability assessment. Our data show that mycetoma is a public health issue with direct implications on quality of life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.