ArticlePLoS neglected tropical diseases2018
Urban yellow fever outbreak-Democratic Republic of the Congo, 2016: Towards more rapid case detection.
Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Epidemiology of yellow fever virus in humans, arthropods, and non-human primates in sub-Saharan Africa: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2022Pooled it
- Estimating case fatality risk of severe Yellow Fever cases: systematic literature review and meta-analysis.BMC infectious diseases · 2021Pooled it
- Integrated surveys of Rift Valley fever, yellow fever and dengue in Lobaye, Central African Republic.One health (Amsterdam, Netherlands) · 2026Article
- Vector competence acrossJournal of virology · 2026Review
- Article
- Revealing viral hepatitis epidemiology in the Democratic Republic of Congo: insights from yellow fever surveillance reanalysis.Tropical medicine and health · 2025Article
- Timeliness of yellow fever specimen collection and transport in Ghana, 2018-2022.PLOS global public health · 2025Article
- Potential role of heterologous flavivirus immunity in preventing urban transmission of yellow fever virus.Nature communications · 2024Article
- Evaluation of the sentinel yellow fever surveillance system in Uganda, 2017-2022: strengths and weaknesses.BMC infectious diseases · 2024Article
- Updating Reproduction Number Estimates for Mpox in the Democratic Republic of Congo Using Surveillance Data.The American journal of tropical medicine and hygiene · 2024Article
- Mosquito-Borne Arboviruses Occurrence and Distribution in the Last Three Decades in Central Africa: A Systematic Literature Review.Microorganisms · 2023Review
- Mosquito gene targeted RNAi studies for vector control.Functional & integrative genomics · 2023Review
- The Impact of Human Activities on Zoonotic Infection Transmissions.Animals : an open access journal from MDPI · 2023Review
- Fractional Dosing of Yellow Fever Live Attenuated 17D Vaccine: A Perspective.Infection and drug resistance · 2023Article
- Factors enhancing the transmission of mosquito-borne arboviruses in Africa.Virusdisease · 2022Review
- First comprehensive analysis of Aedes aegypti bionomics during an arbovirus outbreak in west Africa: Dengue in Ouagadougou, Burkina Faso, 2016-2017.PLoS neglected tropical diseases · 2022Article
- Yellow fever surveillance suggests zoonotic and anthroponotic emergent potential.Communications biology · 2022Article
- High DDT resistance without apparent association to kdr and Glutathione-S-transferase (GST) gene mutations in Aedes aegypti population at hotel compounds in Zanzibar.PLoS neglected tropical diseases · 2022Article
- Sustained circulation of yellow fever virus in Cameroon: an analysis of laboratory surveillance data, 2010-2020.BMC infectious diseases · 2022Article
- High-Throughput Platform for Detection of Neutralizing Antibodies Using Flavivirus Reporter Replicon Particles.Viruses · 2022Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBetween December 2015 and July 2016, a yellow fever (YF) outbreak affected urban areas of Angola and the Democratic Republic of the Congo (DRC). We described the outbreak in DRC and assessed the accuracy of the YF case definition, to facilitate early diagnosis of cases in future urban outbreaks. METHODOLOGY/PRINCIPAL
findingsIn DRC, suspected YF infection was defined as jaundice within 2 weeks after acute fever onset and was confirmed by either IgM serology or PCR for YF viral RNA. We used case investigation and hospital admission forms. Comparing clinical signs between confirmed and discarded suspected YF cases, we calculated the predictive values of each sign for confirmed YF and the diagnostic accuracy of several suspected YF case definitions. Fifty seven of 78 (73%) confirmed cases had travelled from Angola: 88% (50/57) men; median age 31 years (IQR 25-37). 15 (19%) confirmed cases were infected locally in urban settings in DRC. Median time from symptom onset to healthcare consultation was 7 days (IQR 6-9), to appearance of jaundice 8 days (IQR 7-11), to sample collection 9 days (IQR 7-14), and to hospitalization 17 days (IQR 11-26). A case definition including fever or jaundice, combined with myalgia or a negative malaria test, yielded an improved sensitivity (100%) and specificity (57%). CONCLUSIONS/SIGNIFICANCE: As jaundice appeared late, the majority of cases were diagnosed too late for supportive care and prompt vector control. In areas with known local YF transmission, a suspected case definition without jaundice as essential criterion could facilitate earlier YF diagnosis, care and control.
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