ArticleScientific reports2018
Selective abdominal venous congestion induces adverse renal and hepatic morphological and functional alterations despite a preserved cardiac function.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07722325 (Venous Return Pressure Gradient Predicts Acute Kidney Injury Onset and Progression), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Venous Return Pressure Gradient Predicts Acute Kidney Injury Onset and Progression
Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Kidney function trajectories before and after hospitalization for heart failure with reduced ejection fraction.European heart journal · 2025Trial
- Rethinking Congestion in Heart Failure from Volume Overload to Venous Pressure and Organ Disfunction with VExUS.Medicina (Kaunas, Lithuania) · 2026Review
- Assessment of Congestion in Heart Failure Using VExUS: Current Evidence, Limitations and Clinical Perspectives.Life (Basel, Switzerland) · 2026Review
- Lung and Venous Excess Ultrasound Correlation With Intracardiac Pressures Before and After Decongestion in Critically Ill Patients With Acute Decompensated Heart Failure.Critical care explorations · 2026Observational
- Venous congestion from a vascular waterfall perspective: reframing congestion as a dynamic Starling resistor phenomenon.Intensive care medicine experimental · 2025Review
- Experimentally Induced Peripheral Venous Congestion Exacerbates Inflammation, Oxidative Stress, and Neurohormonal and Endothelial Cell Activation in Patients With Systolic Heart Failure.Journal of cardiac failure · 2024Article
- Controlled Mechanical Ventilation in Critically Ill Patients and the Potential Role of Venous Bagging in Acute Kidney Injury.Journal of clinical medicine · 2024Article
- Bio-Humoral and Non-Invasive Haemodynamic Correlates of Renal Venous Flow Patterns across the Heart Failure Spectrum.Medicina (Kaunas, Lithuania) · 2023Article
- Correlations between serum laminin level and severity of heart failure in patients with chronic heart failure.Frontiers in cardiovascular medicine · 2023Article
- High Inferior Vena Cava Diameter with High Left Ventricular End Systolic Diameter as a Risk Factor for Major Adverse Cardiovascular Events, Cardiovascular and Overall Mortality among Chronic Hemodialysis Patients.Journal of clinical medicine · 2022Article
- Renal venous congestion following hemorrhagic shock due to traumatic liver injury.CEN case reports · 2021Article
- First-in-Human Experience of Mechanical Preload Control in Patients With HFpEF During Exercise.JACC. Basic to translational science · 2021Article
- A Novel Non-Invasive Device for the Assessment of Central Venous Pressure in Hospital, Office and Home.Medical devices (Auckland, N.Z.) · 2021Article
- Association of Volume Overload With Kidney Function Outcomes Among Patients With Heart Failure With Reduced Ejection Fraction.Kidney international reports · 2020Article
- Endurance Exercise Intervention Is Beneficial to Kidney Function in a Rat Model of Isolated Abdominal Venous Congestion: a Pilot Study.Journal of cardiovascular translational research · 2020Article
- Utility of collagen-derived peptides as markers of organ injury in patients with acute heart failure.Open heart · 2020Article
- Nitric oxide mediated the effects of nebivolol in cardiorenal syndrome.Iranian journal of basic medical sciences · 2019Article
- Current animal models for the study of congestion in heart failure: an overview.Heart failure reviews · 2019Review
- Maternal Venous Hemodynamic Dysfunction in Proteinuric Gestational Hypertension: Evidence and Implications.Journal of clinical medicine · 2019Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Venous congestion is an important contributor to worsening renal function in heart failure and the cardiorenal syndrome. In patients, it is difficult to study the effects of isolated venous congestion on organ function. In this study, the consequences of isolated abdominal venous congestion on morphology and function of the kidneys, liver and heart were studied in a rat model. Twelve sham-operated (SHAM) male Sprague Dawley rats were compared to eleven inferior vena cava-constricted (IVCc) rats for twenty-one weeks. Abdominal venous pressure was significantly higher in the IVCc versus SHAM group (p < 0.0001). Indices of liver and kidney weight, function and morphology, inflammation as well as collagen deposition were significantly increased in the IVCc compared to SHAM group, (p < 0.05). Echocardiographic and hemodynamic parameters were largely unaffected by abdominal venous congestion. In this rat model of isolated abdominal venous congestion, retrogradely conducted glomerular hypertension without a concomitant change in glomerular filtration rate was observed. Adverse short-term hepatic morphological alterations were developed which explain the observed organ function dysfunction. Importantly, cardiac function remained comparable between both groups. This study provides relevant insight in the pathophysiology of abdominal congestion on organ function.
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