ArticleNature communications2018
A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Fatty acid regulation of feeding inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Atypical tetracyclines promote longevity and ferroptotic neuroprotection via translation attenuation.bioRxiv : the preprint server for biology · 2026Article
- Amitriptyline increases food intake via prdx-2 without altering other physiological parameters in C. elegans under a modified bacterial diet.Scientific reports · 2025Article
- Multiple Targets, One Goal: Compounding life-extending effects through Polypharmacology.bioRxiv : the preprint server for biology · 2024Article
- Quantifying Food Intake in Caenorhabditis elegans by Measuring Bacterial Clearance.Journal of visualized experiments : JoVE · 2024Article
- Hyperleptinemia contributes to antipsychotic drug-associated obesity and metabolic disorders.Science translational medicine · 2023Article
- Research progress in the correlation between SREBP/PCSK9 pathway and lipid metabolism disorders induced by antipsychotics.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Review
- Article
- Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia.Molecular psychiatry · 2023Review
- Network Pharmacology Combined with an Experimental Validation Study to Reveal the Effect and Mechanism ofFoods (Basel, Switzerland) · 2023Article
- Adipocytes control food intake and weight regain via Vacuolar-type HNature communications · 2022Article
- Antipsychotic-induced weight gain and metabolic effects show diurnal dependence and are reversible with time restricted feeding.Schizophrenia (Heidelberg, Germany) · 2022Article
- Gold nanoclusters eliminate obesity induced by antipsychotics.Scientific reports · 2022Article
- Metformin ameliorates olanzapine-induced obesity and glucose intolerance by regulating hypothalamic inflammation and microglial activation in female mice.Frontiers in pharmacology · 2022Article
- Arcuate Nucleus Overexpression of NHLH2 Reduces Body Mass and Attenuates Obesity-Associated Anxiety/Depression-like Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Metabolic and behavioral effects of olanzapine and fluoxetine on the model organismSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2021Article
- Conserved immunomodulatory transcriptional networks underlie antipsychotic-induced weight gain.Translational psychiatry · 2021Article
- Self-Administration of Drugs in Mouse Models of Feeding and Obesity.Journal of visualized experiments : JoVE · 2021Article
- The Gut Microbiome in Schizophrenia and the Potential Benefits of Prebiotic and Probiotic Treatment.Nutrients · 2021Review
- Image-based profiling for drug discovery: due for a machine-learning upgrade?Nature reviews. Drug discovery · 2021Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Antipsychotic (AP) drugs are used to treat psychiatric disorders but are associated with significant weight gain and metabolic disease. Increased food intake (hyperphagia) appears to be a driving force by which APs induce weight gain but the mechanisms are poorly understood. Here we report that administration of APs to C. elegans induces hyperphagia by a mechanism that is genetically distinct from basal food intake. We exploit this finding to screen for adjuvant drugs that suppress AP-induced hyperphagia in C. elegans and mice. In mice AP-induced hyperphagia is associated with a unique hypothalamic gene expression signature that is abrogated by adjuvant drug treatment. Genetic analysis of this signature using C. elegans identifies two transcription factors, nhr-25/Nr5a2 and nfyb-1/NFYB to be required for AP-induced hyperphagia. Our study reveals that AP-induced hyperphagia can be selectively suppressed without affecting basal food intake allowing for novel drug discovery strategies to combat AP-induced metabolic side effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.