Evidence map›Paper›PMID 30531990›Full record

ArticleNature nanotechnology2019

In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment.

Qian Chen, Chao Wang, Xudong Zhang, Guojun Chen, Quanyin Hu, Hongjun Li, Jinqiang Wang, Di Wen, Yuqi Zhang, Yifei Lu and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature nanotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 339 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
339citing papers in PubMed, 1 pooled it
34.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

339 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,000 citations in OpenAlex.

  1. Pooled it
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  7. Article
  8. Review
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  10. Article
  11. Article
  12. Laparoscopic Delivery of a MnOAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  13. Nanovaccines with ferroptosis, necroptosis and STING-activation for synergistic immunotherapy.Journal of experimental & clinical cancer research : CR · 2026
    Article
  14. Review
  15. Article
  16. Article
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  19. Review
  20. National science review · 2026
    Article

279 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Qian ChenDepartment of Bioengineering, University of California, Los Angeles, CA, USA.
Chao WangJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, USA.
Xudong ZhangDepartment of Bioengineering, University of California, Los Angeles, CA, USA.
Guojun ChenDepartment of Bioengineering, University of California, Los Angeles, CA, USA.
Quanyin HuDepartment of Bioengineering, University of California, Los Angeles, CA, USA.
Hongjun LiNational Engineering Research Center for Tissue Restoration and Reconstruction, and School of Biomedical Science and Engineering, South China University of Technology, Guangzhou, Guangdong, China.
Jinqiang WangJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, USA.
Di WenDepartment of Bioengineering, University of California, Los Angeles, CA, USA.
Yuqi ZhangJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, USA.
Yifei LuJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, USA.
Guang YangDepartment of Bioengineering, University of California, Los Angeles, CA, USA.
Chen JiangKey Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China.
Jun WangNational Engineering Research Center for Tissue Restoration and Reconstruction, and School of Biomedical Science and Engineering, South China University of Technology, Guangzhou, Guangdong, China.
Gianpietro DottiLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Zhen GuDepartment of Bioengineering, University of California, Los Angeles, CA, USA. guzhen@ucla.edu.ORCID http://orcid.org/0000-0003-2947-4456
University of North Carolina at Chapel Hill · USCalifornia NanoSystems Institute · USFudan University · CNSouth China University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer recurrence after surgical resection remains a significant cause of treatment failure. Here, we have developed an in situ formed immunotherapeutic bioresponsive gel that controls both local tumour recurrence after surgery and development of distant tumours. Briefly, calcium carbonate nanoparticles pre-loaded with the anti-CD47 antibody are encapsulated in the fibrin gel and scavenge H

Indexed as

AnimalsBiocompatible MaterialsCalcium CarbonateFemaleFibrinGelsHumansImmunityImmunotherapyLuminescent MeasurementsMelanoma, ExperimentalMice, Inbred C57BLNanoparticlesNeoplasm Recurrence, LocalNeoplasmsPhagocytosisBiocompatible MaterialsCalcium CarbonateFibrinGels

Identifiers

PMID30531990
OpenAlexW2902979010

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.