Evidence map›Paper›PMID 30531980›Full record

ArticleNature microbiology2019

Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2.

Daming Zhou, Yuguang Zhao, Abhay Kotecha, Elizabeth E Fry, James T Kelly, Xiangxi Wang, Zihe Rao, David J Rowlands, Jingshan Ren, David I Stuart

Abstract read
PubMed Publisher
In one paragraph

Article in Nature microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 103 citations in OpenAlex.

  1. Trial
  2. Article
  3. Open questions in enterovirus uncoating.Journal of virology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. SPNS1 is an essential cellular factor for EV-A71 by acting as a transporter of viral pocket factor.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Daming ZhouDivision of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-7188-5243
Yuguang ZhaoDivision of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-8916-8552
Abhay KotechaDivision of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-4480-5439
Elizabeth E FryDivision of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-9754-5303
James T KellySchool of Molecular and Cellular Biology, Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK.
Xiangxi WangNational Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing, China.
Zihe RaoNational Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing, China.
David J RowlandsSchool of Molecular and Cellular Biology, Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK.
Jingshan RenDivision of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. ren@strubi.ox.ac.uk.ORCID http://orcid.org/0000-0003-4015-1404
David I StuartDivision of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. dave@strubi.ox.ac.uk.ORCID http://orcid.org/0000-0002-3426-4210
Centre for Human Genetics · GBInstitute of Biophysics · CNThe Pirbright Institute · GBUniversity of Leeds · GB

Funding

Medical Research Council G1100525Medical Research Council MR/N00065X/1
6 · The paper itself

Abstract

Enterovirus 71 (EV71) is a common cause of hand, foot and mouth disease-a disease endemic especially in the Asia-Pacific region

Indexed as

Host Microbial InteractionsCryoelectron MicroscopyEnterovirusHumansLysosomal Membrane ProteinsReceptors, ScavengerViral ProteinsVirus AttachmentLysosomal Membrane ProteinsReceptors, ScavengerSCARB2 protein, humanViral Proteins

Identifiers

PMID30531980
OpenAlexW2902339840

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.