ArticleNature microbiology2019
GABA-modulating bacteria of the human gut microbiota.
2 registry-linked trialsAbstract read
In one paragraph
Article in Nature microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 641 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
641citing papers in PubMed, 8 pooled it
30.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of the Gut Microbiome as Determinant of Depression in Multiple Sclerosis Subjects
The Protective Role of Preoperative Stimulation of the Distal Limb of the Ileostomy Loop With GABA Before Ileostomy Closure
Who cites it
641 citing papers in PubMed, 8 syntheses or guidelines pooled it, 1,105 citations in OpenAlex.
- A systematic review of molecular signaling in the muscle-brain-gut axis: exercise-induced myokines and microbial metabolites as key mediators.Molecular biology reports · 2026Pooled it
- Neurotransmitter-mediated gut-brain axis: a bibliometric analysis of research trends and knowledge structure.Frontiers in microbiology · 2026Pooled it
- Neurobiological insights into perinatal depression: a multi-dimensional integration of brain structure, function, and metabolism.Frontiers in psychiatry · 2026Pooled it
- Mediterranean diet and gut microbiota: impact on memory and other cognitive functions: a systematic review.Frontiers in molecular neuroscience · 2026Pooled it
- Pharmaco-psychiatry and gut microbiome: a systematic review of effects of psychotropic drugs for bipolar disorder.Microbiology (Reading, England) · 2025Pooled it
- Gut microbiota variations in depression and anxiety: a systematic review.BMC psychiatry · 2025Pooled it
- Gut-brain axis and neuroplasticity in health and disease: a systematic review.La Radiologia medica · 2025Pooled it
- Effects of probiotics on patients with Prader-Willi syndrome: a systematic review and meta-analysis of randomized controlled trials.Frontiers in nutrition · 2025Pooled it
- Effects ofFrontiers in psychiatry · 2026Trial
- Effects of kefir on symptoms, sleep, and gut microbiota in children with ADHD: a randomised controlled trial.BMC psychiatry · 2025Trial
- Baseline gut microbiome and metabolites are correlated with changes in alcohol consumption in participants in a randomized Zonisamide clinical trial.Scientific reports · 2025Trial
- GutMIND: A multi-cohort machine learning framework for integrative characteristics of the microbiota-gut-brain axis in neuropsychiatric disorders.Gut microbes · 2026Article
- Oral Actinomyces Species Exposure is Associated with Anxiety-Like Behavior, Mitochondrial Remodeling, and Altered GABAergic Pathways.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Next-generation probiotics and microbiome-based therapeutics highlighting Akkermansia muciniphila and Amuc_1100.World journal of microbiology & biotechnology · 2026Review
- From Dysbiosis to Blood-Brain Barrier Disruption: The Metabolite-Mediated Gut-Brain Axis in Alzheimer's Disease.Molecular neurobiology · 2026Review
- Gut-microbiome composition, single nucleotide polymorphisms, and differentially expressed genes correlate with aggression in an ant.iScience · 2026Article
- Unraveling the Mechanistic Insights ofNutrients · 2026Review
- Delivering the Gut to the Brain: Drug Delivery Strategies for Microbiota-Derived Therapeutics in Depression.Pharmaceutics · 2026Review
- Major Depressive Disorder Signatures: A Review of Artificial Intelligence (AI)-Powered Insights Into Gut Dysbiosis.Health science reports · 2026Article
- Empirical evidence for gut microbial influence on human brain neurochemistry via the gut-brain axis.Molecular psychiatry · 2026Article
581 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 5 institutions in 2 countries.
Philip StrandwitzAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA. p.strandwitz@northeastern.edu.
Ki Hyun KimDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5285-9138
Darya TerekhovaDepartment of Psychiatry and Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY, USA.
Joanne K LiuBioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA, USA.
Anukriti SharmaDepartment of Surgery, University of Chicago, Chicago, IL, USA.
Jennifer LeveringCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA.
Daniel McDonaldDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-0876-9060
David DietrichDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Timothy R RamadharDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7063-5445
Asama LekbuaAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA.
Nader MroueAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA.
Conor ListonDepartment of Psychiatry and Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY, USA.
Eric J StewartAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA.
Marc J DubinDepartment of Psychiatry and Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY, USA.
Karsten ZenglerCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-8062-3296
Rob KnightCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-0975-9019
Jack A GilbertDepartment of Surgery, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-7920-7001
Jon ClardyDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0213-8356
Kim LewisAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA. k.lewis@neu.edu.ORCID http://orcid.org/0000-0002-1621-7664
Northeastern University · USUniversity of California San Diego · USHarvard University · USCornell University · USArgonne National Laboratory · US
Funding
Persister cells of Borrelia burgdorferiR01AI122286 · NIAID · NORTHEASTERN UNIVERSITY · PI HU, LINDEN T, LEWIS, KIM · 2016 to 2019
$2.3MCulturing Uncultivatable Gut MicroorganismsR01HG005824 · NHGRI · NORTHEASTERN UNIVERSITY · PI LEWIS, KIM · 2010 to 2012
$1.4MDiscovery of Potential Therapeutic Agents from Insect-Associated Symbiotic BacterF32GM108415 · NIGMS · HARVARD MEDICAL SCHOOL · PI RAMADHAR, TIMOTHY RAMESAR · 2014 to 2015
$106kNHGRI NIH HHS R01 HG005824NIAID NIH HHS R01 AI122286NIGMS NIH HHS F32 GM108415
Abstract
The gut microbiota affects many important host functions, including the immune response and the nervous system
Indexed as
Gastrointestinal MicrobiomeAdultAgedBacteriaBacteroidesBrainCohort StudiesDepressionFecesFemalegamma-Aminobutyric AcidGastrointestinal TractGene Expression ProfilingHumansMagnetic Resonance ImagingMajor Depressive Disordergamma-Aminobutyric Acid
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT05808101ClinicalTrials.gov
NCT05905393ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.