ArticleScientific reports2018
The autosomal Gsdf gene plays a role in male gonad development in Chinese tongue sole (Cynoglossus semilaevis).
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 40 citations in OpenAlex.
- Sex-specific gonadal transcriptome during early development of Siberian sturgeon.Biology of sex differences · 2026Article
- Sex- and stage-dependent expression of gonadal soma-derived factor paralogues reveals functional and evolutionary divergence in European sea bass (Frontiers in endocrinology · 2026Article
- Functional Analysis of the Cyclin E Gene in the Reproductive Development of Rainbow Trout (Biology · 2025Article
- Identification and Expression Pattern ofAnimals : an open access journal from MDPI · 2022Article
- A Z-Linked E3 Ubiquitin LigaseAnimals : an open access journal from MDPI · 2021Article
- Involvement of Transforming Growth Factor Beta Family Genes in Gonadal Differentiation in Japanese Eel,Cells · 2021Article
- Article
- Evolution, Expression, and Function of Gonadal Somatic Cell-Derived Factor.Frontiers in cell and developmental biology · 2021Review
- Transcriptomic analysis of dead end knockout testis reveals germ cell and gonadal somatic factors in Atlantic salmon.BMC genomics · 2020Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Gsdf is a key gene for testicular differentiation in teleost. However, little is known about the function of Gsdf in Chinese tongue sole (Cynoglossus semilaevis). In this study, we obtained the full-length Gsdf gene (CS-Gsdf), and functional characterization revealed its potential participation during germ cell differentiation in testes. CS-Gsdf transcription was predominantly detected in gonads, while the levels in testes were significantly higher than those in ovaries. During the different developmental stages in male gonads, the mRNA level was significantly upregulated at 86 dph, and a peak appeared at 120 dph; then, the level decreased at 1 and 2 yph. In situ hybridization revealed that CS-Gsdf mRNA was mainly localized in the Sertoli cells, spermatogonia, and spermatids in mature testes. After CS-Gsdf knockdown in the male testes cell line by RNA interference, a series of sex-related genes was influenced, including several sex differentiation genes, CS-Wnt4a, CS-Cyp19a1a and CS-Star. Based on these data, we speculated that CS-Gsdf may play a positive role in germ differentiation and proliferation via influencing genes related to sex differentiation.
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