Evidence map›Paper›PMID 30531969›Full record

ArticleNature communications2018

PDL2

Leticia Tordesillas, Daniel Lozano-Ojalvo, David Dunkin, Lucie Mondoulet, Judith Agudo, Miriam Merad, Hugh A Sampson, M Cecilia Berin

Abstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Skin-lung axis in the atopic march: The immune link from skin to lungs.Chinese medical journal pulmonary and critical care medicine · 2025
    Review
  5. Review
  6. Regulation and application of mScience China. Life sciences · 2025
    Review
  7. Article
  8. Apoptosis and Cell Clearance in Skin Wound Healing.Advances in experimental medicine and biology · 2025
    Review
  9. Review
  10. Review
  11. Dendritic cells in food allergy, treatment, and tolerance.The Journal of allergy and clinical immunology · 2024
    Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Leticia TordesillasPediatric Allergy & Immunology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.
Daniel Lozano-OjalvoPediatric Allergy & Immunology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.
David DunkinPediatric Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Lucie MondouletDBV Technologies, Montrouge, 90120, France.
Judith AgudoImmunology Institute. Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.
Miriam MeradImmunology Institute. Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.
Hugh A SampsonPediatric Allergy & Immunology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.
M Cecilia BerinPediatric Allergy & Immunology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA. cecilia.berin@mssm.edu.

Funding

Role of T cells in gastrointestinal manifestations of food allergyR01AI093577 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BERIN, CECILIA · 2012 to 2016
$2.1M
Epicutaneous Tolerance Induction for the Treatment of ColitisK08DK102978 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DUNKIN, DAVID · 2015 to 2018
$635k
Communication between skin and gastrointestinal tract in food allergyR21AI124062 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BERIN, CECILIA · 2016 to 2017
$466k
Epicutaneous Tolerance Induction with Flagellin Epitopes for the Treatment of ColitisR03DK117218 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DUNKIN, DAVID · 2018 to 2019
$170k
NIAID NIH HHS R01 AI093577NIAID NIH HHS R21 AI124062NIDDK NIH HHS K08 DK102978NIDDK NIH HHS R03 DK117218NIH HHS AI093577NIH HHS AI124062NIH HHS K08DK102978
6 · The paper itself

Abstract

The skin immune system must discriminate between innocuous antigens and pathogens. Antigen applied topically using a Viaskin® patch elicits immune tolerance that can suppress colitis and food allergy. Here we show how topical antigen is acquired and presented by dendritic cells in the skin. Topical antigen is acquired by Langerhans cells (LC) and CD11b

Indexed as

AnimalsAntigen PresentationAntigensCD11b AntigenDendritic CellsDermisHair FollicleLangerhans CellsMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutPeptidesProgrammed Cell Death 1 Ligand 2 ProteinProtein PrecursorsSkinT-Lymphocytes, RegulatoryAntigensCD11b Antigenlatency-associated propeptide, TGF-betaPdcd1lg2 protein, mousePeptidesProgrammed Cell Death 1 Ligand 2 ProteinProtein PrecursorsTransforming Growth Factor beta

Identifiers

PMID30531969
PMCPMC6286332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.