Evidence map›Paper›PMID 30531954›Full record

SynthesisBone marrow transplantation2019

Ocular graft-versus-host disease after hematopoietic cell transplantation: Expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT.

Yoshihiro Inamoto, Nuria Valdés-Sanz, Yoko Ogawa, Monica Alves, Luigi Berchicci, John Galvin, Hildegard Greinix, Gregory A Hale, Biljana Horn, Debra Kelly and 30 more

Registry-linked trialOpen access · bronzeAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Bone marrow transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04946721 (2177GCCC), which is not on this map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04946721 recruitingnot on this mapstarted 2022, after this paper: background citation

2177GCCC: Identifying Novel Treatment Targets and Biomarkers for Ocular Surface Disease in Patients With Ocular Graft vs Host Disease (oGVHD) a Biobank Study

TypeobservationalSponsorUniversity of Maryland, BaltimoreRan2022 to 2027Enrolled150ConditionsDry Eye Disease, oGVHDArmsThe standard care exam and biological specimens' collection
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Exosomes in ocular graft-versus-host disease: an overview.International journal of ophthalmology · 2026
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. [Chinese expert consensus on ocular chronic graft-versus-host disease (2023)].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors at 20 institutions in 12 countries.

Yoshihiro Inamoto *Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan. yinamoto@ncc.go.jp.
Nuria Valdés-Sanz *Department of Ophthalmology, Hospital Universitario Puerta de Hierro, Madrid, Spain.
Yoko OgawaDepartment of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Monica AlvesDepartment of Ophthalmology, University of Campinas, Campinas, Brazil.
Luigi BerchicciDepartment of Ophthalmology, San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy.
John GalvinDepartment of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Hildegard GreinixBone Marrow Transplantation Unit, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.
Gregory A HaleDepartment of Hematology/Oncology, Johns Hopkins All Children's Hospital, St., Petersburg, FL, USA.
Biljana HornShands HealthCare and University of Florida, Gainesville, FL, USA.
Debra KellyShands HealthCare and University of Florida, Gainesville, FL, USA.
Hien LiuH. Lee Moffitt Cancer Center Cleveland, Cleveland, OH, USA.
Scott RowleyHackensack University Medical Center, Washington, DC, USA.
Helene SchoemansUniversity Hospital of Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-7568-8239
Ami ShahDivision of Stem Cell Transplantation and Regenerative Medicine, Lucille Packard Children's Hospital, Stanford School of Medicine, Palo Alto, CA, USA.
Maria Teresa Lupo StanghelliniUnit of Hematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, Milano, Italy.
Vaibhav AgrawalSimon Cancer Center, Indiana University, Indianapolis, IN, USA.
Ibrahim AhmedDepartment of Hematology Oncology and Bone Marrow Transplantation, The Children's Mercy Hospitals and Clinics, Kansas City, MO, USA.
Asim AliDepartment of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Neel BhattCIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Michael ByrneVanderbilt University Medical Center, Nashville, TN, USA.
Saurabh ChhabraCIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Zack DeFilippBlood and Marrow Transplant Program, Massachusetts General Hospital, Boston, MA, USA.
Kristina FahnehjelmDepartment of Clinical Neuroscience, Karolinska Institutet, St. Erik Eye Hospital, Stockholm, Sweden.
Nosha FarhadfarShands HealthCare and University of Florida, Gainesville, FL, USA.
Erich HornShands HealthCare and University of Florida, Gainesville, FL, USA.
Catherine LeeUtah Blood and Marrow Transplant Program Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Sunita NathanRush University Medical Center, Chicago, IL, USA.
Olaf PenackDepartment of Internal Medicine, Division of Haematology and Oncology, Charité University Medicine, Campus Rudolf Virchow, Berlin, Germany.
Pinki PrasadLousiana State University Children's Hospital, New Orleans, LA, USA.
Seth RotzCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Alicia RovóInselspital, Universitatsspital Bern, Bern, Switzerland.
Jean YaredBlood and Marrow Transplantation Program, Division of Hematology/Oncology, Department of Medicine, Greenebaum Cancer Center, University of Maryland, Baltimore, MD, USA.
Steven PavleticExperimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Grzegorz W BasakMedical University of Warsaw, Warsaw, Poland.ORCID http://orcid.org/0000-0003-3858-8180
Minoo BattiwallaHematology Branch, Sarah Cannon BMT Program, Nashville, TN, USA.
Rafael DuarteUniversity Hospital Puerta de Hierro, Madrid, Spain.
Bipin N SavaniDivision of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Mary E D FlowersClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Bronwen E ShawCIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Igor Petriček *Department of Ophthalmology, University Clinical Hospital Zagreb, Zagreb, Croatia.
University of Florida Health · USMedical College of Wisconsin · USHospital Universitario Puerta de Hierro Majadahonda · ESVanderbilt University Medical Center · USVita-Salute San Raffaele University · ITCharité - Universitätsmedizin Berlin · DEChildren's Hospital of New Orleans · USChildren's Mercy Hospital · USCincinnati Children's Hospital Medical Center · USFred Hutch Cancer Center · USHackensack University Medical Center · USIndiana University Health · USJohns Hopkins University · USKarolinska Institutet · SEKeio University · JPLucile Packard Children's Hospital · USMassachusetts General Hospital · USMedical University of Vienna · ATMedical University of Warsaw · PLMoffitt Cancer Center · US

Funding

Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
Easy-to-read Informed Consent for HCT Clinical TrialsU10HL069294 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HOROWITZ, MARY MARESCA · 2011 to 2016
$43.8M
NCI NIH HHS U24 CA076518NHLBI NIH HHS U10 HL069294
6 · The paper itself

Abstract

Ocular graft-versus-host disease (GVHD) occurs in more than half of patients who develop chronic GVHD after allogeneic hematopoietic cell transplantation (HCT), causing prolonged morbidity, which affects activities of daily living and quality of life. Here we provide an expert review of ocular GVHD in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Recent updates in ocular GVHD, regarding pathophysiology, preclinical models, risk factors, prevention, screening, diagnosis, response criteria, evaluation measures, and treatment are discussed in this review. Ocular GVHD has at least three biological processes: lacrimal gland dysfunction, meibomian gland dysfunction, and corneoconjunctival inflammation. Preclinical models have found several novel pathogenic mechanisms, including renin angiotensin system and endoplasmic reticulum stress signaling that can be targeted by therapeutic agents. Many studies have identified reliable tests for establishing diagnosis and response assessment of ocular GVHD. Efficacy of systemic and topical treatment for ocular GVHD is summarized. It is important for all health professionals taking care of HCT recipients to have adequate knowledge of ocular GVHD for optimal care.

Indexed as

Hematopoietic Stem Cell TransplantationAllograftsEye DiseasesGraft vs Host DiseaseHumansInflammation

Identifiers

PMID30531954
OpenAlexW2905578697

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.