ArticleNature communications2018
GWAS identifies 14 loci for device-measured physical activity and sleep duration.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05153941 (DNS Cohort Study Aimed at Understanding the Pathophysiology of AD and AD Related Disorders), which is not on this map. Cited by 220 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
DNS Cohort Study Aimed at Understanding the Pathophysiology of AD and AD Related Disorders (ADRD)
Who cites it
220 citing papers in PubMed, 11 syntheses or guidelines pooled it.
- A contextual genomic perspective on physical activity and its relationship to health, well being and illness.Nature genetics · 2025Pooled it
- Reviewing the association between motor competence and physical activity from a behavioral genetic perspective.Frontiers in psychology · 2025Pooled it
- Causal Association Between Sedentary Behaviors and Health Outcomes: A Systematic Review and Meta-Analysis of Mendelian Randomization Studies.Sports medicine (Auckland, N.Z.) · 2024Pooled it
- Testing the causal relationships of physical activity and sedentary behaviour with mental health and substance use disorders: a Mendelian randomisation study.Molecular psychiatry · 2023Pooled it
- Postdiagnosis recreational physical activity and breast cancer prognosis: Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis.International journal of cancer · 2023Pooled it
- Emerging trends and hot spots of sleep and genetic research: a bibliometric analysis of publications from 2002 to 2022 in the field.Frontiers in neurology · 2023Pooled it
- Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.Nature genetics · 2022Pooled it
- Causal effects of psychosocial factors on chronic back pain: a bidirectional Mendelian randomisation study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Pooled it
- Systematic review of Mendelian randomization studies on risk of cancer.BMC medicine · 2022Pooled it
- Relationships between accelerometer-measured and multiple sclerosis: a 2-sample Mendelian randomization study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Pooled it
- Genetic variants related to physical activity or sedentary behaviour: a systematic review.The international journal of behavioral nutrition and physical activity · 2021Pooled it
- Molecular correlates of sleep deprivation in the mouse brain identified by meta-analysis of microarray data.Neurobiology of sleep and circadian rhythms · 2026Article
- Article
- Accelerometer-derived real-world sleep stages and risk of incident diseases: A UK Biobank cohort study and phenome-wide association analysis.PLoS medicine · 2026Article
- Wearable sensor-derived continuous physical activity dimensions and all-cause mortality in adults with diabetes and hypertension: insights from two population-based accelerometry cohorts.Acta diabetologica · 2026Article
- Wearable Movement-Tracking for Prodromal Parkinson's Disease Detection: A Cross-Country Validation Study.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Accelerometer-Measured Moderate-to-Vigorous Physical Activity and Cancer Risk: Dose-Response from Observational and Nonlinear Mendelian Randomization in UK Biobank.Healthcare (Basel, Switzerland) · 2026Article
- Polygenic Risk Scores for Breast Cancer Among African American Women With High Risk.JAMA network open · 2026Article
- Evidence for overlapping genetic architecture between lifestyle factors and severe mental disorders with different patterns across diagnoses.EBioMedicine · 2026Article
- The causality between physical activity and gestational diabetes mellitus: a Mendelian randomization study.Molecular genetics and genomics : MGG · 2026Article
160 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Physical activity and sleep duration are established risk factors for many diseases, but their aetiology is poorly understood, partly due to relying on self-reported evidence. Here we report a genome-wide association study (GWAS) of device-measured physical activity and sleep duration in 91,105 UK Biobank participants, finding 14 significant loci (7 novel). These loci account for 0.06% of activity and 0.39% of sleep duration variation. Genome-wide estimates of ~ 15% phenotypic variation indicate high polygenicity. Heritability is higher in women than men for overall activity (23 vs. 20%, p = 1.5 × 10
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.