ArticleScientific reports2018
High-efficiency freezing-induced loading of inorganic nanoparticles and proteins into micron- and submicron-sized porous particles.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Photoacoustic monitoring of freezing-induced loading and freeze-casting processes.Biomedical optics express · 2025Article
- Efficacy of Submicron Vaterite-Based Drug Carriers in Mitigating Doxorubicin-Induced Liver Injury.Bulletin of experimental biology and medicine · 2025Article
- Quantum Diamond Microscopy of Individual Vaterite Microspheres Containing Magnetite Nanoparticles.Nanomaterials (Basel, Switzerland) · 2025Article
- Large-scale super-resolution optoacoustic imaging facilitated by FeNP/ICG-loaded coreless polyelectrolyte microcapsules.Theranostics · 2025Article
- Scalable Copper Sulfide Formulations for Super-Resolution Optoacoustic Brain Imaging in the Second Near-Infrared Window.Small methods · 2025Article
- Article
- Microfluidically Assisted Synthesis of Calcium Carbonate Submicron Particles with Improved Loading Properties.Micromachines · 2023Article
- Exploiting Benefits of Vaterite Metastability to Design Degradable Systems for Biomedical Applications.Pharmaceutics · 2023Review
- Plug-and-Play Lymph Node-on-Chip: Secondary Tumor Modeling by the Combination of Cell Spheroid, Collagen Sponge and T-Cells.International journal of molecular sciences · 2023Article
- Gold Nanorod-Incorporated Halloysite Nanotubes Functionalized with Antibody for Superior Antibacterial Photothermal Treatment.Pharmaceutics · 2022Article
- The Influence of Magnetic Composite Capsule Structure and Size on Their Trapping Efficiency in the Flow.Molecules (Basel, Switzerland) · 2022Article
- Calcium carbonate vaterite particles for drug delivery: Advances and challenges.Materials today. Advances · 2022Review
- Micro/Nanosystems for Magnetic Targeted Delivery of Bioagents.Pharmaceutics · 2022Review
- Degradation of Hybrid Drug Delivery Carriers with a Mineral Core and a Protein-Tannin Shell under Proteolytic Hydrolases.Biomimetics (Basel, Switzerland) · 2022Article
- Hard, Soft, and Hard-Pharmaceutics · 2022Review
- Effect of Size on Magnetic Polyelectrolyte Microcapsules Behavior: Biodistribution, Circulation Time, Interactions with Blood Cells and Immune System.Pharmaceutics · 2021Article
- Indocyanine green dye based bimodal contrast agent tested by photoacoustic/fluorescence tomography setup.Biomedical optics express · 2021Article
- Dynamic blood flow phantom for in vivo liquid biopsy standardization.Scientific reports · 2021Article
- Biodegradable polyelectrolyte/magnetite capsules for MR imaging and magnetic targeting of tumors.Nanotheranostics · 2021Article
- Freezing-Induced Loading of TiOACS omega · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
We demonstrate a novel approach to the controlled loading of inorganic nanoparticles and proteins into submicron- and micron-sized porous particles. The approach is based on freezing/thawing cycles, which lead to high loading densities. The process was tested for the inclusion of Au, magnetite nanoparticles, and bovine serum albumin in biocompatible vaterite carriers of micron and submicron sizes. The amounts of loaded nanoparticles or substances were adjusted by the number of freezing/thawing cycles. Our method afforded at least a three times higher loading of magnetite nanoparticles and a four times higher loading of protein for micron vaterite particles, in comparison with conventional methods such as adsorption and coprecipitation. The capsules loaded with magnetite nanoparticles by the freezing-induced loading method moved faster in a magnetic field gradient than did the capsules loaded by adsorption or coprecipitation. Our approach allows the preparation of multicomponent nanocomposite materials with designed properties such as remote control (e.g. via the application of an electromagnetic or acoustic field) and cargo unloading. Such materials could be used as multimodal contrast agents, drug delivery systems, and sensors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.