ArticleNature chemical biology2019
Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis.
Article in Nature chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 88 citations in OpenAlex.
- Heterogeneity of iridoid biosynthesis in catmints: Molecular background in a phylogenetic context.Journal of integrative plant biology · 2026Article
- Discovery of iridoid cyclase completes the iridoid pathway in asterids.Nature plants · 2025Article
- The missing link in the iridoid puzzle.Nature plants · 2025Article
- Haplotype-resolved genome ofHorticulture research · 2025Article
- Via Air or Rhizosphere: The Phytotoxicity ofPlants (Basel, Switzerland) · 2025Review
- Enhancing Substrate Preference of Iridoid Synthase via Focused Polarity-Steric Mutagenesis Scanning.Chem & bio engineering · 2024Article
- Pseudomolecule-scale genome assemblies of Drepanocaryum sewerzowii and Marmoritis complanata.G3 (Bethesda, Md.) · 2024Article
- CRISPR-Cas9-based genome-editing technologies in engineering bacteria for the production of plant-derived terpenoids.Engineering microbiology · 2024Review
- Haplotype-phased genome unveils the butylphthalide biosynthesis and homoploid hybrid origin ofScience advances · 2024Article
- Integrating cotyledon-based virus-induced gene silencing with visual marker promises a rapid, highly effective validation of gene functions inFrontiers in plant science · 2024Article
- Molecular background of the diverse metabolic profiles in leaves and inflorescences of naked catmint (Frontiers in plant science · 2024Article
- Development of the gas chromatography/mass spectrometry-based aroma designer capable of modifying volatile chemical compositions in complex odors.Chemical senses · 2024Article
- Characterization of the horse chestnut genome reveals the evolution of aescin and aesculin biosynthesis.Nature communications · 2023Article
- Review
- Plant terpene specialized metabolism: complex networks or simple linear pathways?The Plant journal : for cell and molecular biology · 2023Review
- Transcriptome analysis and exploration of genes involved in the biosynthesis of secoiridoids inPeerJ · 2023Article
- Successive harvests affect the aromatic and polyphenol profiles of novel catnip (Frontiers in plant science · 2023Article
- Grapevine genome analysis demonstrates the role of gene copy number variation in the formation of monoterpenes.Frontiers in plant science · 2023Article
- Functional iridoid synthases from iridoid producing and non-producingFrontiers in plant science · 2023Article
- Biosynthesis of iridoid sex pheromones in aphids.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Terpene synthases typically form complex molecular scaffolds by concerted activation and cyclization of linear starting materials in a single enzyme active site. Here we show that iridoid synthase, an atypical reductive terpene synthase, catalyzes the activation of its substrate 8-oxogeranial into a reactive enol intermediate, but does not catalyze the subsequent cyclization into nepetalactol. This discovery led us to identify a class of nepetalactol-related short-chain dehydrogenase enzymes (NEPS) from catmint (Nepeta mussinii) that capture this reactive intermediate and catalyze the stereoselective cyclisation into distinct nepetalactol stereoisomers. Subsequent oxidation of nepetalactols by NEPS1 provides nepetalactones, metabolites that are well known for both insect-repellent activity and euphoric effects in cats. Structural characterization of the NEPS3 cyclase reveals that it binds to NAD
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.