Evidence map›Paper›PMID 30531828›Full record

ArticleScientific reports2018

Space- and time-resolved investigation on diffusion kinetics of human skin following macromolecule delivery by microneedle arrays.

Jonathan C J Wei, Isha N Haridass, Michael L Crichton, Yousuf H Mohammed, Stefano C Meliga, Washington Y Sanchez, Jeffrey E Grice, Heather A E Benson, Michael S Roberts, Mark A F Kendall

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Jonathan C J WeiDiamantina Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, QLD, 4102, Australia.ORCID http://orcid.org/0000-0003-0222-5425
Isha N HaridassDiamantina Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, QLD, 4102, Australia.
Michael L CrichtonInstitute of Mechanical, Process and Energy Engineering, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, United Kingdom.
Yousuf H MohammedDiamantina Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, QLD, 4102, Australia.
Stefano C MeligaAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD, 4072, Australia.
Washington Y SanchezDiamantina Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, QLD, 4102, Australia.
Jeffrey E GriceDiamantina Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, QLD, 4102, Australia.
Heather A E BensonSchool of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, 6102, Australia.
Michael S RobertsDiamantina Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, QLD, 4102, Australia. m.roberts@uq.edu.au.
Mark A F KendallAustralian National University, Canberra, ACT, 0200, Australia. mark.kendall@anu.edu.au.
The University of Queensland · AUAustralian National University · AUCurtin University · AUHeriot-Watt University · GB

Funding

Department of Health | National Health and Medical Research Council (NHMRC) 1107356
6 · The paper itself

Abstract

Microscale medical devices are being developed for targeted skin delivery of vaccines and the extraction of biomarkers, with the potential to revolutionise healthcare in both developing and developed countries. The effective clinical development of these devices is dependent on understanding the macro-molecular diffusion properties of skin. We hypothesised that diffusion varied according to specific skin layers. Using three different molecular weights of rhodamine dextran (RD) (MW of 70, 500 and 2000 kDa) relevant to the vaccine and therapeutic scales, we deposited molecules to a range of depths (0-300 µm) in ex vivo human skin using the Nanopatch device. We observed significant dissipation of RD as diffusion with 70 and 500 kDa within the 30 min timeframe, which varied with MW and skin layer. Using multiphoton microscopy, image analysis and a Fick's law analysis with 2D cartesian and axisymmetric cylindrical coordinates, we reported experimental trends of epidermal and dermal diffusivity values ranging from 1-8 µm

Indexed as

Administration, CutaneousAdultDermisDextransDiffusionDrug Delivery SystemsEpidermisFemaleHumansKineticsMolecular WeightNeedlesRhodaminesSkin AbsorptionVaccinesDextransrhodamine dextranRhodaminesVaccines

Identifiers

PMID30531828
PMCPMC6288161
OpenAlexW2902541860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.