Evidence map›Paper›PMID 30531686›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2018

Hypoxia-Inducible Factor 1 alpha (HIF-1α)/Vascular Endothelial Growth Factor (VEGF) Pathway Participates in Angiogenesis of Myocardial Infarction in Muscone-Treated Mice: Preliminary Study.

Yingqiang Du, Yingbin Ge, Zhihui Xu, Nan Aa, Xin Gu, Haoyu Meng, Zhou Lin, Dongxiao Zhu, Jingjing Shi, Ruijuan Zhuang and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical science monitor : international medical journal of experimental and clinical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Yingqiang DuDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China (mainland).
Yingbin GeDepartment of Physiology, Nanjing Medical University, Nanjing, Jiangsu, China (mainland).
Zhihui XuDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China (mainland).
Nan AaDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China (mainland).
Xin GuDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China (mainland).
Haoyu MengDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China (mainland).
Zhou LinDepartment of Cardiology, Wuxi No. 3 People's Hospital Affiliated to Nantong University, Wuxi, Jiangsu, China (mainland).
Dongxiao ZhuDepartment of Cardiac Ultrasound, Wuxi No. 3 People's Hospital Affiliated to Nantong University, Wuxi, Jiangsu, China (mainland).
Jingjing ShiDepartment of Cardiology, Wuxi No. 3 People's Hospital Affiliated to Nantong University, Wuxi, Jiangsu, China (mainland).
Ruijuan ZhuangDepartment of Cardiology, Wuxi No. 3 People's Hospital Affiliated to Nantong University, Wuxi, Jiangsu, China (mainland).
Xueming WuDepartment of Cardiology, Wuxi No. 3 People's Hospital Affiliated to Nantong University, Wuxi, Jiangsu, China (mainland).
Xiaoyan WangDepartment of Cardiology, Wuxi No. 3 People's Hospital Affiliated to Nantong University, Wuxi, Jiangsu, China (mainland).
Zhijian YangDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China (mainland).
Jiangsu Province Hospital · CNNanjing Medical University · CNWuxi No.2 People's Hospital · CNNantong University · CNWuxi Third People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND Angiogenesis plays a crucial role in myocardial infarction (MI) treatment by ameliorating myocardial remodeling, thus improving cardiac function and preventing heart failure. Muscone has been reported to have beneficial effects on cardiac remodeling in MI mice. However, the effects of muscone on angiogenesis in MI mice and its underlying mechanisms remain unknown. MATERIAL AND METHODS Mice were randomly divided into sham, MI, and MI+muscone groups. The MI mouse model was established by ligating the left anterior descending coronary artery. Mice in the sham group received the same procedure except for ligation. Mice were administered muscone or an equivalent volume of saline for 4 consecutive weeks. Cardiac function was evaluated by echocardiograph after MI for 2 and 4 weeks. Four weeks later, all mice were sacrificed and Masson's trichrome staining was used to assess myocardial fibrosis. Isolectin B4 staining was applied to evaluate the angiogenesis in mouse hearts. Immunohistochemistry, Western blot analysis, and quantitative real-time polymerase chain reaction (qPCR) were performed to analyze expression levels of HIF-1a and its downstream genes. RESULTS Compared with the MI group, muscone treatment significantly improved cardiac function and reduced myocardial fibrosis. Moreover, muscone enhanced angiogenesis in the peri-infarct region and p-VEGFR2 expression in the vascular endothelial cells. Western blot analysis and qPCR showed that muscone upregulated expression levels of HIF-1a and VEGFA. CONCLUSIONS Muscone improved cardiac function in MI mice through augmented angiogenesis. The potential mechanism of muscone treatment in regulating angiogenesis of MI mice was upregulating expression levels of HIF-1α and VEGFA.

Indexed as

Angiogenesis Inducing AgentsAnimalsCycloparaffinsDisease Models, AnimalEchocardiographyHypoxia-Inducible Factor 1, alpha SubunitMaleMiceMice, Inbred C57BLMyocardial InfarctionMyocardiumNeovascularization, PathologicNeovascularization, PhysiologicPreliminary DataVascular Endothelial Growth Factor AVentricular Function, LeftAngiogenesis Inducing AgentsCycloparaffinsHypoxia-Inducible Factor 1, alpha SubunitmusconeVascular Endothelial Growth Factor A

Identifiers

PMID30531686
PMCPMC6295139
OpenAlexW2904021455

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.