ArticleClinical and experimental otorhinolaryngology2019
Role of Immunohistochemistry in Fine Needle Aspiration and Core Needle Biopsy of Thyroid Nodules.
Article in Clinical and experimental otorhinolaryngology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 20 citations in OpenAlex.
- Influencing factors and prediction model of ultrasound-based false-negative central lymph node metastasis in localized papillary thyroid carcinoma.Gland surgery · 2026Article
- Advantages of thyroid core needle biopsy: an emerging selective first-line biopsy modality.Ultrasonography (Seoul, Korea) · 2026Article
- Core Needle Biopsy (CNB) and Immunohistochemical Markers in Indeterminate Thyroid Nodules: Evidence and Perspectives.Endocrine, metabolic & immune disorders drug targets · 2026Review
- FHL1: A novel diagnostic marker for papillary thyroid carcinoma.Pathology international · 2024Article
- A comparative analysis of core needle biopsy and repeat fine needle aspiration in patients with inconclusive initial cytology of thyroid nodules.Frontiers in endocrinology · 2024Article
- [Evaluation of accuracy of pathological diagnosis based on thyroid core needle biopsy].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
- The parotid gland, an unusual site of colorectal cancer metastasis.Ecancermedicalscience · 2023Article
- Immunohistochemistry in the pathologic diagnosis and management of thyroid neoplasms.Frontiers in endocrinology · 2023Review
- Thermography as an aid for the complementary diagnosis of nodules in the thyroid gland.Biomedical engineering online · 2022Article
- Application of biomarkers in the diagnosis of uncertain samples of core needle biopsy of thyroid nodules.Virchows Archiv : an international journal of pathology · 2021Article
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3 authors at 2 institutions in 1 country.
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Abstract
objectivesImmunohistochemistry (IHC) has been used for the diagnosis of indeterminate results in fine needle aspiration (FNA) of thyroid nodules. However, the role of IHC in core needle biopsy (CNB) is not clear and the efficacy of testing for molecular markers following CNB has not been evaluated. The aim of this study is to compare the role of IHC staining in CNB with that in FNA when examining thyroid nodules and to compare the sensitivity and usefulness of different molecular markers.
methodsConsecutive cases of thyroid FNA and CNB accompanied by IHC from 2004 to 2014 were included in this study with retrospective review of medical record. The rate of remaining nondiagnostic result (unsatisfactory, atypia of undetermined significance or follicular lesion of undetermined significance [AUS/FLUS]) and rate of strong expression of each molecular marker according to the diagnosis were evaluated.
resultsIHC was more frequently performed in CNB with multiple molecular markers compared to FNA (38.1% vs. 2.8%, 3 or 4 markers [Gal-3, HBME-1, CK19, and CD56] vs. 1 marker [Gal-3]). In the CNB group, 11.3% remained as AUS/FLUS after IHC, and the rate remaining nondiagnostic was significantly less than in the FNA group (42.9%). Gal-3 and CK19 showed higher specificity and expressed mainly in conventional type of papillary carcinoma and HBME-1 showed higher sensitivity for the diagnosis of carcinoma with expression in both conventional type and follicular variant papillary thyroid carcinoma.
conclusionWith these data, we could conclude that IHC was more effective following CNB than following FNA.
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