ArticleThe journal of trauma and acute care surgery2019
Platelet dysfunction during trauma involves diverse signaling pathways and an inhibitory activity in patient-derived plasma.
Article in The journal of trauma and acute care surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Time Course of Hemostatic Disruptions After Traumatic Brain Injury: A Systematic Review of the Literature.Neurocritical care · 2021Pooled it
- The absence of ADAMTS13 improves early outcomes in an experimental model of trauma with uncontrolled hemorrhage.The journal of trauma and acute care surgery · 2026Article
- Lyophilized platelet derived extracellular vesicles promote hemostasis and attenuate intracranial hemorrhage following traumatic brain injury.Journal of translational medicine · 2026Article
- Utility of point-of-care platelet aggregation testing for transfusion prediction.Scientific reports · 2026Article
- The hidden battlefield: platelet function in the wake of severe trauma.Frontiers in immunology · 2026Review
- Viscoelastic Hemostatic Assays in the Management of Trauma-Induced Coagulopathy: A Clinical Update.Journal of clinical medicine · 2025Review
- When the victim becomes the villain: Platelets as drivers of immune dysregulation in ITP.Journal of translational autoimmunity · 2025Review
- Hemostatic abnormalities after trauma resuscitation: challenges and strategies in caring for the critically injured patient.Annals of intensive care · 2025Review
- Beyond the count: platelet dysfunction profile in pediatric trauma patients.Research and practice in thrombosis and haemostasis · 2025Article
- CD63 Immunological Activation Versus Hemostatic Function: Platelet Alterations After Polytrauma.Current issues in molecular biology · 2025Article
- Multiscale simulations that incorporate patient-specific neural network models of platelet calcium signaling predict diverse thrombotic outcomes under flow.PLoS computational biology · 2025Article
- Traumatic brain injury: Advances in coagulopathy (Review).Biomedical reports · 2024Review
- Blood failure: traumatic hemorrhage and the interconnections between oxygen debt, endotheliopathy, and coagulopathy.Clinical and experimental emergency medicine · 2024Article
- Trauma patients have reduced ex vivo flow-dependent platelet hemostatic capacity in a microfluidic model of vessel injury.PloS one · 2024Article
- Decoding thrombosis through code: a review of computational models.Journal of thrombosis and haemostasis : JTH · 2024Review
- Elevation of White Blood Cell Subtypes in Adult Trauma Patients with Stress-Induced Hyperglycemia.Diagnostics (Basel, Switzerland) · 2023Article
- Effects of the circulating environment of COVID-19 on platelet and neutrophil behavior.Frontiers in immunology · 2023Article
- Importance of catecholamine signaling in the development of platelet exhaustion after traumatic injury.Journal of thrombosis and haemostasis : JTH · 2022Article
- Review
- A three-dimensional multiscale model for the prediction of thrombus growth under flow with single-platelet resolution.PLoS computational biology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundTrauma-induced coagulopathy occurs in about 25% of injured patients and accounts for about 10% of deaths worldwide. Upon injury, hemostatic function may decline due to vascular dysfunction, clotting factor deficiencies, hyperfibrinolysis, and/or platelet dysfunction. We investigated agonist-induced calcium signaling in platelets obtained over time from trauma patients.
methodsPlatelets from trauma patients and healthy donors were monitored via intracellular calcium mobilization and flow cytometry markers (α2bβ3 activation, P-selectin display, and phosphatidylserine exposure) following stimulation with a panel of agonists (adenosine 5'-diphosphate sodium salt, U46619, convulxin, PAR-1/4 activating peptides, iloprost) used in isolation or in pairwise tests. Furthermore, healthy donor platelets were tested in heterologous plasma isolated from healthy subjects and trauma patients.
resultsWhen exposed to agonists over the first 24 hours postinjury, trauma patient platelets mobilized less calcium in comparison to healthy platelets. Partial recovery of platelet activity was observed in about a third of patients after 120 hours, although not fully obtaining healthy baseline function. Flow cytometry markers of trauma platelets were similar to healthy platelets prior to stimulation, but were depressed in trauma platelets stimulated with adenosine 5'-diphosphate sodium salt or convulxin. Also, washed healthy platelets showed a significant reduction in calcium mobilization when reconstituted in plasma from trauma patients, relative to healthy plasma, at all plasma doses tested.
conclusionPlatelet dysfunction in trauma patients included poor response to multiple agonists relevant to hemostatic function. Furthermore, the inhibitor effect of patient plasma on healthy platelets suggests that soluble plasma species may downregulate endogenous or transfused platelets during trauma.
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