ArticlePain2019
The relationship between catastrophizing and altered pain sensitivity in patients with chronic low-back pain.
Article in Pain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04798469 (Androgen Replacement to Improve Patient-Important Outcomes in Men With Opioid-Induced Hypogonadism), which is not on this map. Cited by 78 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Androgen Replacement to Improve Patient-Important Outcomes in Men With Opioid-Induced Hypogonadism
Who cites it
78 citing papers in PubMed, 154 citations in OpenAlex.
- Autonomic indices of negative emotion regulation predict treatment response in opioid-treated chronic low back pain.The journal of pain · 2026Trial
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- Lipid and metabolic alteration involvement in physiotherapy for chronic nonspecific low back pain.Lipids in health and disease · 2022Trial
- The Effects of Combined Respiratory-Gated Auricular Vagal Afferent Nerve Stimulation and Mindfulness Meditation for Chronic Low Back Pain: A Pilot Study.Pain medicine (Malden, Mass.) · 2022Trial
- Trial
- Altered somatosensory temporal discrimination in chronic non-specific low back pain patients with central sensitization-related features: a cross-sectional study.The Korean journal of pain · 2026Article
- Brain activity alterations following lumbar discectomy in people with chronic low back pain.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Demographic patterns in quantitative sensory testing and clinical pain among former professional American-style football players.Pain reports · 2026Article
- Observational
- Profile and association between pain sensitivity and physical fitness in individuals with chronic low back pain.BMC musculoskeletal disorders · 2026Article
- Central Sensitization as a Marker of Cognitive and Emotional Vulnerability in Chronic Low Back Pain.Brain sciences · 2026Article
- Assessment of central pain sensitization in chronic low back pain and its utility in diagnosis and prediction of clinical severity.Scientific reports · 2026Article
- The Role of Catastrophizing in Enhancing Pain Interference and Depressive Symptoms in Endometriosis: A Longitudinal Examination.European journal of pain (London, England) · 2026Article
- Frozen Shoulder Is More Than Local Pain: Widespread Sensory Hyperalgesia or Hypoesthesia?European journal of pain (London, England) · 2026Observational
- Concurrent changes in psychological distress and pain thresholds following brief mindfulness: an exploratory phenotyping study of chronic pain.Frontiers in psychology · 2026Article
- Male and female workers suffering from chronic low back pain display different interrelationships between the biopsychosocial variables.Journal of rehabilitation medicine · 2025Article
- Central aspects of pain associated with physical activity: results from the Investigating Musculoskeletal Health and Wellbeing cohort.Pain reports · 2025Article
- Catastrophizing and fear avoidance beliefs in chronic low back pain: a cross-sectional study.European journal of physical and rehabilitation medicine · 2025Article
- Physiological Sensor Modality Sensitivity Test for Pain Intensity Classification in Quantitative Sensory Testing.Sensors (Basel, Switzerland) · 2025Article
- Pain profiles and variability in temporal summation of pain and conditioned pain modulation in pain-free individuals and patients with low back pain, osteoarthritis, and fibromyalgia.European journal of pain (London, England) · 2025Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 7 institutions in 1 country.
Funding
Abstract
Changes in central pain processing have been shown in patients with chronic low-back pain (cLBP). We used quantitative sensory testing methods to identify differences in pain sensitization between patients with cLBP (N = 167) and healthy controls (N = 33). Results indicated that, compared with healthy pain-free controls, cLBP patients showed increased sensitivity and greater painful aftersensations for mechanical pressure and pin-prick stimuli and lower tactile spatial acuity in the 2-point discrimination task (ps < 0.05). Then, we examined the role of pain catastrophizing as a mediator of the group differences in pain sensitization. We found that catastrophizing partially accounted for group differences in pressure required to produce moderate pain. Finally, we examined the relationship between pain sensitization, catastrophizing, and clinical pain among patients with cLBP. We found that catastrophizing and deep-tissue pressure pain were associated with greater pain intensity in the past month, week, and at the visit as well as low-back pain bothersomeness. Furthermore, deep-tissue pressure pain mediated the associations between catastrophizing and both pain in the past month and low-back pain severity. Taken together, these results indicate that not only do patients with cLBP demonstrate increased pain sensitization and decreased sensitivity to innocuous stimuli, but these changes are also linked with increased catastrophizing. Furthermore, both catastrophizing and sensitization are associated with increased clinical pain among cLBP patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.