ArticleAnnals of Saudi medicine
Persistence of hepatitis B surface antibody and immune memory to hepatitis B vaccine among medical college students in Madinah.
Article in Annals of Saudi medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Investigation the longevity of hepatitis B surface antibody in vaccinated students of Hormozgan university of medical sciences.Iranian journal of microbiology · 2023Article
- Impaired humoral immune response to hepatitis B vaccine in patients on maintenance hemodialysis.Saudi journal of biological sciences · 2023Article
- Hepatitis B virus immunity prior to and after administration of a 'booster' dose of vaccine among health-care students at a South African university.Vaccine: X · 2023Article
- Epidemiology of Chronic Hepatitis B Infection in the Cohort of College Students with Vaccination in Taiwan.Vaccines · 2023Article
- Seroprotection of Hepatitis B Vaccine in Dental Students Two Decades after Infant Immunization and the Possible Need for Revaccination.European journal of dentistry · 2023Article
- Review
- The seroprevalence of the hepatitis B virus in Italian medical students after 3 decades since the introduction of universal vaccination.International journal of occupational medicine and environmental health · 2022Observational
- Human Cytomegalovirus Seroprevalence Among Blood Donors in the Madinah Region, Saudi Arabia.Cureus · 2022Article
- Persistence of hepatitis B surface antibody to hepatitis B vaccine among medical college students in Najran University, Saudi Arabia.Bioinformation · 2022Article
- Article
- Assessment of SARS-CoV-2 Anti-Spike IgG Antibody in Women and Children in Madinah, Saudi Arabia: A Single-Center Study.International journal of environmental research and public health · 2021Article
- Association of Viral Load in SARS-CoV-2 Patients With Age and Gender.Frontiers in medicine · 2021Article
- Kinetics of Anti-Hepatitis B Surface Antigen Titers in Nurse Students after a Two-Year Follow-Up.Vaccines · 2020Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlobally, about 300 million people are infected with hepatitis B virus (HBV). Among the effective approaches to fight HBV infection is immunization. In 1989, an obligatory hepatitis B vaccine program was launched in Saudi Arabia.
objectiveAssess hepatitis B surface antibody (anti-HBs) levels among the medical students before and after receiving booster doses of HBV vaccine.
designCross-sectional.
settingTaibah University. SUBJECTS AND
methodsStudents born between 1993 and 1995 were recruited in this study from the Occupational Health Clinic. Students were screened for anti-HBs levels using chemiluminescent microparticle immunoassay (CMIA) before and after booster HBV vaccine doses.
main outcome measuresAnti-HBs levels before and after booster doses. SAMPLE SIZE: 335.
resultsAbout half of participants (n=164, 49%) had protective anti-HBs levels ( greater than or equal 10 mIU/mL) to the original primary series of HBV vaccine and received no booster doses. The reimaining 171 (51%) participants were at risk of HBV infection since their anti-HBs levels were less than 10 mIU/mL, despite having received the original primary HBV vaccine. The levels of anti-HBs were higher in female than in male students (P less than .001). In addition, female students showed a stronger humoral immune response to the booster vaccine than male students (P less than .001). When participants were given the three boosters, most participants (98.3%) showed anti-HBs levels of greater than or equal 10 mIU/mL. The results also showed a strong correlation between pre-booster and post-booster anti-HBs levels in the greater than or equal 10 mIU/mL group (r2= 0.52, P less than .001) but not in less than 10 mIU/mL group (r2= 0.003, P=.53).
conclusionA considerable portion of the participants (about 51%) were at risk of HBV infection since their anti-HBs levels were less than 10 mIU/mL. Booster doses significantly trigger memory immune response and this ensured their protection against the virus. Pre-booster anti-HBs level are a good predictive of post-booster anti-HBs levels in greater than or equal 10 mIU/mL group. LIMITATIONS: The sample size was small. Shortage of collaborators. CONFLICT OF INTEREST: None.
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