Evidence map›Paper›PMID 30531122›Full record

ArticleJournal of epidemiology2020

Decline in Handgrip Strength From Midlife to Late-Life is Associated With Dementia in a Japanese Community: The Hisayama Study.

Yozo Hatabe, Mao Shibata, Tomoyuki Ohara, Emi Oishi, Daigo Yoshida, Takanori Honda, Jun Hata, Shigenobu Kanba, Takanari Kitazono, Toshiharu Ninomiya

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In one paragraph

Article in Journal of epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  9. [Grip strength and high blood pressure: a case-control study].Revista medica del Instituto Mexicano del Seguro Social · 2024
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yozo HatabeDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University.ORCID http://orcid.org/0000-0002-8880-0269
Mao ShibataDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University.ORCID http://orcid.org/0000-0002-4468-6214
Tomoyuki OharaDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University.
Emi OishiDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University.
Daigo YoshidaDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University.
Takanori HondaDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University.ORCID http://orcid.org/0000-0002-1011-9879
Jun HataDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University.
Shigenobu KanbaDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University.
Takanari KitazonoCenter for Cohort Studies, Graduate School of Medical Sciences, Kyushu University.
Toshiharu NinomiyaDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University.ORCID http://orcid.org/0000-0003-1345-9032

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe association between decline in handgrip strength from midlife to late life and dementia is unclear.

methodsJapanese community-dwellers without dementia aged 60 to 79 years (ie, individuals in late life; mean age, 68 years) were followed for 24 years (1988-2012) (n = 1,055); 835 of them had participated in a health examination in 1973-1974 (mean age, 53 years), and these earlier data were used for the midlife analysis. Using a Cox proportional hazards model, we estimated the risk conferred by a decline in handgrip strength over a 15-year period (1973-74 to 1988) from midlife to late life on the development of total dementia, Alzheimer's disease (AD), and vascular dementia (VaD) over the late-life follow-up period from 1988 to 2012.

resultsDuring the follow-up, 368 subjects experienced total dementia. The age- and sex-adjusted incidence of total dementia increased significantly with greater decline in handgrip strength (increased or unchanged handgrip strength [≥+0%] 25.1, mildly decreased [-14 to -1%] 28.4, and severely decreased [≤-15%] 38.9 per 1,000 person-years). A greater decline in handgrip strength was significantly associated with higher risk of total dementia after adjusting for potential confounding factors; subjects with severely decreased handgrip strength had 1.51-fold (95% confidence interval, 1.14-1.99, P < 0.01) increased risk of total dementia compared to those with increased or unchanged handgrip strength. Similar significant findings were observed for AD, but not for VaD.

conclusionsOur findings suggest that a greater decline in handgrip strength from midlife to late life is an important indicator for late-life onset of dementia.

Indexed as

AgedAgingDementiaFemaleHand StrengthHumansJapanLongitudinal StudiesMaleMiddle AgedRisk FactorsAlzheimer’s diseasedementiaepidemiologyhandgrip strengthlongitudinal study

Identifiers

PMID30531122
PMCPMC6908846

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.