ArticleNeural regeneration research2019
Predator stress-induced depression is associated with inhibition of hippocampal neurogenesis in adult male mice.
Article in Neural regeneration research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- The effect of SSRIs on unconditioned anxiety: a systematic review and meta-analysis of animal studies.Psychopharmacology · 2024Pooled it
- Maternal depression and offspring neurodevelopmental impairments in wild rodents induced by ecologically relevant prenatal stress.Molecular psychiatry · 2026Article
- Adult hippocampal neurogenesis: New avenues for treatment of brain disorders.Stem cell reports · 2025Review
- Distinct subpopulations of ventral pallidal cholinergic projection neurons encode valence of olfactory stimuli.Cell reports · 2024Article
- Distinct subpopulations of ventral pallidal cholinergic projection neurons encode valence of olfactory stimuli.bioRxiv : the preprint server for biology · 2023Article
- Fasting produces antidepressant-like effects via activating mammalian target of rapamycin complex 1 signaling pathway in ovariectomized mice.Neural regeneration research · 2023Article
- A diabetes-like biochemical and behavioural phenotype ofProceedings. Biological sciences · 2023Article
- Neurocognitive effects of stress: a metaparadigm perspective.Molecular psychiatry · 2023Review
- The Evolving Role of Animal Models in the Discovery and Development of Novel Treatments for Psychiatric Disorders.Advances in neurobiology · 2023Article
- The neuroimmunology of social-stress-induced sensitization.Nature immunology · 2022Review
- Corticotropin-releasing factor induces functional and structural synaptic remodelling in acute stress.Translational psychiatry · 2021Article
- Immune receptor toll-like receptor 4 contributes to stress-induced affective responses in a sex-specific manner.Brain, behavior, & immunity - health · 2021Article
- Understanding stress: Insights from rodent models.Current research in neurobiology · 2021Review
- Physical Stress Induced Reduction of Proliferating Cells and Differentiated Neuroblasts Is Ameliorated by FermentedMarine drugs · 2020Article
- Rodent models of post-traumatic stress disorder: behavioral assessment.Translational psychiatry · 2020Review
- Animal models of major depression: drawbacks and challenges.Journal of neural transmission (Vienna, Austria : 1996) · 2019Review
- Corticotropin-Releasing Factor Receptors in the Locus Coeruleus Modulate the Enhancement of Active Coping Behaviors Induced by Chronic Predator Odor Inoculation in Mice.Frontiers in psychology · 2019Article
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stress has been suggested to disturb the 5-hydroxytryptamine system and decrease neurogenesis, which contribute to the development of depression. Few studies have investigated the effect of predator stress, a type of psychological stress, on depression and hippocampal neurogenesis in adult mice; we therefore investigated this in the present study. A total of 35 adult male Kunming mice were allocated to a cat stress group, cat odor stress group, cat stress + fluoxetine group, cat odor stress + fluoxetine group, or a control group (no stress/treatment). After 12 days of cat stress or cat odor stress, behavioral correlates of depression were measured using the open field test, elevated plus maze test, and dark-avoidance test. The concentrations of hippocampal 5-hydroxytryptamine and 5-hydroxyindoleacetic acid were measured using high-performance liquid chromatography-electrochemical detection. Neurogenesis was also analyzed using a bromodeoxyuridine and doublecortin double-immunostaining method. Cat stress and cat odor stress induced depression-like behaviors; this effect was stronger in the cat stress model. Furthermore, compared with the control group, cat stress mice exhibited lower 5-hydroxytryptamine concentrations, higher 5-hydroxyindoleacetic acid concentrations, and significantly fewer bromodeoxyuridine
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