Evidence map›Paper›PMID 30530815›Full record

ArticleCancer research2019

miR-192-5p Silencing by Genetic Aberrations Is a Key Event in Hepatocellular Carcinomas with Cancer Stem Cell Features.

Yuanzhuo Gu, Xiyang Wei, Yulin Sun, Hongjun Gao, Xin Zheng, Linda L Wong, Ling Jin, Niya Liu, Brenda Hernandez, Karolina Peplowska and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 97 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Hepatocellular Carcinoma Around the Clock.Current oncology (Toronto, Ont.) · 2026
    Review
  5. Evaluation of hepatic cancer stem cells (CDMolecular biology reports · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. iScience · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 3 countries.

Yuanzhuo GuLife Sciences Institute, Zhejiang University, Hangzhou, Zhejiang Province, China.
Xiyang WeiLife Sciences Institute, Zhejiang University, Hangzhou, Zhejiang Province, China.
Yulin SunState Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Hongjun GaoUniversity of Hawai'i Cancer Center, Honolulu, Hawaii.
Xin ZhengEZKIT Llc, Honolulu, Hawaii.
Linda L WongUniversity of Hawai'i Cancer Center, Honolulu, Hawaii.
Ling JinUniversity of Hawai'i Cancer Center, Honolulu, Hawaii.
Niya LiuLife Sciences Institute, Zhejiang University, Hangzhou, Zhejiang Province, China.
Brenda HernandezUniversity of Hawai'i Cancer Center, Honolulu, Hawaii.
Karolina PeplowskaUniversity of Hawai'i Cancer Center, Honolulu, Hawaii.
Xiaohang ZhaoState Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Qi-Min ZhanKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China.
Xin-Hua FengLife Sciences Institute, Zhejiang University, Hangzhou, Zhejiang Province, China.
Zhao-You TangLiver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China.
Junfang JiLife Sciences Institute, Zhejiang University, Hangzhou, Zhejiang Province, China. junfangji@zju.edu.cn.
Zhejiang University · CNCancer Center of Hawaii · USChinese Academy of Medical Sciences & Peking Union Medical College · CNFudan University · CNHawaii Department of Health · USMeitan General Hospital · CNMinistry of Education · ETUniversity of Hawaiʻi at Mānoa · US

Funding

University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2M
NCI NIH HHS P30 CA071789
6 · The paper itself

Abstract

Various cancer stem cell (CSC) biomarkers have been identified for hepatocellular carcinoma (HCC), but little is known about the implications of heterogeneity and shared molecular networks within the CSC population. Through miRNA profile analysis in an HCC cohort (

Indexed as

AnimalsBiomarkers, TumorBlood ProteinsCarcinoma, HepatocellularCell Line, TumorCohort StudiesDNA MethylationDown-RegulationGene Regulatory NetworksHEK293 CellsHep G2 CellsHeterograftsHumansLiver NeoplasmsMaleMiceBiomarkers, TumorBlood ProteinsMicroRNAsMIRN192 microRNA, humanPABPC4 protein, humanPoly(A)-Binding Proteins

Identifiers

PMID30530815
PMCPMC6397664
OpenAlexW2904262345

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.