Evidence map›Paper›PMID 30530798›Full record

ReviewNeurology2019

Translating the biology of aging into novel therapeutics for Alzheimer disease.

Yuko Hara, Nicholas McKeehan, Howard M Fillit

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  15. Exploring the effect of gut microbiome on Alzheimer's disease.Biochemistry and biophysics reports · 2024
    Review
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  17. Article
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  19. Review
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yuko HaraFrom the Alzheimer's Drug Discovery Foundation, New York, NY.
Nicholas McKeehanFrom the Alzheimer's Drug Discovery Foundation, New York, NY.
Howard M FillitFrom the Alzheimer's Drug Discovery Foundation, New York, NY. hfillit@alzdiscovery.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is the leading risk factor for most chronic illnesses of old age, including Alzheimer disease (AD), a progressive neurodegenerative disease with currently no therapies that prevent, slow, or halt disease progression. Like other chronic diseases of old age, the progressive pathology of AD begins decades before the onset of symptoms. Many decades of research in biological gerontology have revealed common processes that are relevant to understanding why the aging brain is vulnerable to AD. In this review, we frame the development of novel therapeutics for AD in the context of biological gerontology. The many therapies currently in development based on biological gerontology principles provide promise for the development of a new generation of therapeutics to prevent and treat AD.

Indexed as

AgingAlzheimer DiseaseAnimalsDisease ProgressionHumansTranslational Research, Biomedical

Identifiers

PMID30530798
PMCPMC6340342

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.