Evidence map›Paper›PMID 30530783›Full record

ArticleThe Journal of biological chemistry2019

Inhibitors of energy metabolism interfere with antibiotic-induced death in mycobacteria.

Bei Shi Lee, Nitin P Kalia, Xin Er F Jin, Erik J Hasenoehrl, Michael Berney, Kevin Pethe

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 71 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Metabolic perturbation reduces antibiotic tolerance inMicrobiology (Reading, England) · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Metabolic rewiring of isoniazid sensitivity inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Target Identification in Anti-Tuberculosis Drug Discovery.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Bei Shi LeeFrom the School of Biological Sciences, Nanyang Technological University, Singapore 637551.
Nitin P Kaliathe Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, and.
Xin Er F Jinthe Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, and.
Erik J Hasenoehrlthe Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461.
Michael Berneythe Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461.ORCID 0000-0002-4833-0573
Kevin PetheFrom the School of Biological Sciences, Nanyang Technological University, Singapore 637551, kevin.pethe@ntu.edu.sg.
Nanyang Technological University · SGAlbert Einstein College of Medicine · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · NIGMS · YESHIVA UNIVERSITY · PI AKABAS, MYLES H. · 1985 to 2022
$35.6M
Eradicating persistent M. tuberculosis by synthetic lethality of terminal respiratory oxidasesR01AI139465 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BERNEY, MICHAEL · 2019 to 2023
$3.2M
Targeting terminal respiratory oxidation in Mycobacterium tuberculosis: A novel investigation of Cytochrome bd oxidase functionF30AI138483 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HASENOEHRL, ERIK · 2018 to 2018
$50k
NIAID NIH HHS F30 AI138483NIAID NIH HHS R01 AI139465NIGMS NIH HHS T32 GM007288
6 · The paper itself

Abstract

Energy metabolism has recently gained interest as a target space for antibiotic drug development in mycobacteria. Of particular importance is bedaquiline (Sirturo), which kills mycobacteria by inhibiting the F

Indexed as

Adenosine TriphosphateAnti-Bacterial AgentsAntitubercular AgentsBacterial ProteinsDrug DesignElectron Transport Chain Complex ProteinsEnergy MetabolismIsoniazidMoxifloxacinMycobacteriumOxidative PhosphorylationProton-Translocating ATPasesAdenosine TriphosphateAnti-Bacterial AgentsAntitubercular AgentsBacterial ProteinsElectron Transport Chain Complex ProteinsIsoniazidMoxifloxacinProton-Translocating ATPasesantagonismantibioticsATPBedaquilinecell deathMycobacterium tuberculosisoxidative phosphorylationQ203Telacebectuberculosis

Identifiers

PMID30530783
PMCPMC6369303
OpenAlexW2903871664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.