Evidence map›Paper›PMID 30530632›Full record

ReviewEMBO reports2019

Peroxisome biogenesis, membrane contact sites, and quality control.

Jean-Claude Farré, Shanmuga S Mahalingam, Marco Proietto, Suresh Subramani

Open access · bronzeAbstract readReview
In one paragraph

Review in EMBO reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 160 citations in OpenAlex.

  1. Article
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  6. Review
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  13. Article
  14. Aging impairs peroxisome biogenesis in human B cells.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Article
  15. Review
  16. Signing protein-protein interaction networks.Bioinformatics (Oxford, England) · 2026
    Article
  17. Article
  18. Article
  19. Article
  20. Article

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jean-Claude FarréSection of Molecular Biology, Division of Biological Sciences, University of California, San Diego, CA, USA.
Shanmuga S MahalingamSection of Molecular Biology, Division of Biological Sciences, University of California, San Diego, CA, USA.
Marco ProiettoSection of Molecular Biology, Division of Biological Sciences, University of California, San Diego, CA, USA.
Suresh SubramaniSection of Molecular Biology, Division of Biological Sciences, University of California, San Diego, CA, USA ssubramani@ucsd.edu.ORCID 0000-0003-0180-1742
University of California San Diego · US

Funding

TARGETING OF PROTEINS INTO PEROXISOMESR01DK041737 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AITCHISON, JOHN D., SUBRAMANI, SURESH · 1990 to 2025
$8.4M
NIDDK NIH HHS R01 DK041737
6 · The paper itself

Abstract

Peroxisomes are conserved organelles of eukaryotic cells with important roles in cellular metabolism, human health, redox homeostasis, as well as intracellular metabolite transfer and signaling. We review here the current status of the different co-existing modes of biogenesis of peroxisomal membrane proteins demonstrating the fascinating adaptability in their targeting and sorting pathways. While earlier studies focused on peroxisomes as autonomous organelles, the necessity of the ER and potentially even mitochondria as sources of peroxisomal membrane proteins and lipids has come to light in recent years. Additionally, the intimate physical juxtaposition of peroxisomes with other organelles has transitioned from being viewed as random encounters to a growing appreciation of the expanding roles of such inter-organellar membrane contact sites in metabolic and regulatory functions. Peroxisomal quality control mechanisms have also come of age with a variety of mechanisms operating both during biogenesis and in the cellular response to environmental cues.

Indexed as

Endoplasmic ReticulumEukaryotic CellsHomeostasisHumansMembrane ProteinsMetabolic Networks and PathwaysMitochondriaMitochondrial MembranesOxidation-ReductionPeroxisomesMembrane Proteinsde novo peroxisome biogenesisperoxisomal membrane contact sitesperoxisomal membrane protein biogenesisperoxisome growth and divisionperoxisome quality control

Identifiers

PMID30530632
PMCPMC6322382
OpenAlexW2904405727

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.