Evidence map›Paper›PMID 30530595›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

Characterization of Mauritian Cynomolgus Macaque FcγR Alleles Using Long-Read Sequencing.

Amelia K Haj, Jaren M Arbanas, Aaron P Yamniuk, Julie A Karl, Hailey E Bussan, Kenneth Y Drinkwater, Michael E Graham, Adam J Ericsen, Trent M Prall, Kristina Moore and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

Amelia K HajDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53705.ORCID 0000-0002-1453-341X
Jaren M ArbanasBristol-Myers Squibb, Princeton, NJ 08648; and.ORCID 0000-0002-5068-1495
Aaron P YamniukBristol-Myers Squibb, Princeton, NJ 08648; and.
Julie A KarlDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53705.
Hailey E BussanDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53705.
Kenneth Y DrinkwaterWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715.
Michael E GrahamWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715.
Adam J EricsenWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715.ORCID 0000-0003-4176-8270
Trent M PrallWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715.
Kristina MooreBristol-Myers Squibb, Princeton, NJ 08648; and.ORCID 0000-0001-8751-4597
Lin ChengBristol-Myers Squibb, Princeton, NJ 08648; and.
Mian GaoBristol-Myers Squibb, Princeton, NJ 08648; and.
Robert F GrazianoBristol-Myers Squibb, Princeton, NJ 08648; and.
John T LoffredoBristol-Myers Squibb, Princeton, NJ 08648; and.
Roger W WisemanDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53705.
David H O'ConnorDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53705; dhoconno@wisc.edu.ORCID 0000-0003-2139-470X
University of Wisconsin–Madison · USBristol-Myers Squibb (United States) · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
Research Training for Computation and Informatics in Biology and MedicineT15LM007359 · NLM · UNIVERSITY OF WISCONSIN-MADISON · PI Mark W. Craven, Colin Noel Dewey · 2002 to 2026
$22.6M
INTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTST32GM008692 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E · 1998 to 2020
$10.3M
Identifying Common T Cell Responses to Major Pathogens in Rhesus MacaquesR24OD017850 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI O'CONNOR, DAVID H. · 2014 to 2022
$5.8M
Virology Training ProgramT32AI078985 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI LAMBERT, PAUL F. · 2009 to 2018
$3.3M
NIAID NIH HHS T32 AI078985NIGMS NIH HHS T32 GM008692NIH HHS P51 OD011106NIH HHS R24 OD017850NLM NIH HHS T15 LM007359
6 · The paper itself

Abstract

The FcγRs are immune cell surface proteins that bind IgG and facilitate cytokine production, phagocytosis, and Ab-dependent, cell-mediated cytotoxicity. FcγRs play a critical role in immunity; variation in these genes is implicated in autoimmunity and other diseases. Cynomolgus macaques are an excellent animal model for many human diseases, and Mauritian cynomolgus macaques (MCMs) are particularly useful because of their restricted genetic diversity. Previous studies of MCM immune gene diversity have focused on the MHC and killer cell Ig-like receptor. In this study, we characterize FcγR diversity in 48 MCMs using PacBio long-read sequencing to identify novel alleles of each of the four expressed MCM

Indexed as

GenotypeMacaca fascicularisAllelesAnimalsAntibody-Dependent Cell CytotoxicityGene FrequencyHaplotypesHigh-Throughput Nucleotide SequencingHumansImmunityImmunoglobulin GModels, AnimalProtein BindingReceptors, IgGImmunoglobulin GReceptors, IgG

Identifiers

PMID30530595
PMCPMC6314804
OpenAlexW2904713347

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.