ArticleThe Journal of biological chemistry2019
Hepatocyte-specific Sirt6 deficiency impairs ketogenesis.
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Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Review
- Decoding organ fibrosis: mechanistic insights and emerging therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Ultrasound-driven ROS-scavenging nanobubbles for synergistic NASH treatment via FXR activation.Ultrasonics sonochemistry · 2025Article
- PPARα regulates ER-lipid droplet protein Calsyntenin-3β to promote ketogenesis in hepatocytes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Metabolic mechanisms orchestrated by Sirtuin family to modulate inflammatory responses.Frontiers in immunology · 2024Review
- Pachymic acid modulates sirtuin 6 activity to alleviate lipid metabolism disorders.Experimental and therapeutic medicine · 2023Article
- Review
- Ginsenoside Rc, as an FXR activator, alleviates acetaminophen-induced hepatotoxicityFrontiers in pharmacology · 2022Article
- Loss of Sirt6 in adipocytes impairs the ability of adipose tissue to adapt to intermittent fasting.Experimental & molecular medicine · 2021Article
- Inhibition of 5-Lipoxygenase in Hepatic Stellate Cells Alleviates Liver Fibrosis.Frontiers in pharmacology · 2021Article
- A unifying mechanism of ketogenic diet action: The multiple roles of nicotinamide adenine dinucleotide.Epilepsy research · 2020Review
- Sirt6 in pro-opiomelanocortin neurons controls energy metabolism by modulating leptin signaling.Molecular metabolism · 2020Article
- SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα.Cell reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 4 institutions in 2 countries.
Lei ChenDepartment of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Qinhui LiuLaboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Qin TangDepartment of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Jiangying KuangDepartment of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Hong LiDepartment of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Shiyun PuDepartment of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Tong WuDepartment of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Xuping YangDepartment of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Rui LiDepartment of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Jinhang ZhangDepartment of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Zijing ZhangDepartment of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Ya HuangDepartment of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Yanping LiDepartment of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Min ZouDepartment of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China.
Wei JiangMolecular Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Tao LiWest China-Washington Mitochondria and Metabolism Center and Laboratory of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Meng GongWest China-Washington Mitochondria and Metabolism Center and Laboratory of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Lu ZhangWest China-Washington Mitochondria and Metabolism Center and Laboratory of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Hua WangDepartment of Oncology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Aijuan QuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China 100069.
Wen XieCenter for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260. Electronic address: wex6@pitt.edu.
Jinhan HeDepartment of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: jinhanhe@scu.edu.cn.
Sichuan University · CNAnhui Medical University · CNCapital Medical University · CNUniversity of Pittsburgh · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sirt6 is an NADH (NAD
Indexed as
AnimalsHepatocytesKetone BodiesLipid MetabolismMaleMiceMice, Inbred C57BLMice, KnockoutProteinsSirtuinsfat-specific protein 27, mouseKetone BodiesProteinsSirt6 protein, mouseSirtuinsfatty acid metabolismlipidlipid dropletlipid metabolismlipogenesisliverliver metabolismmetabolic diseasetranscription regulation
Identifiers
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.