Evidence map›Paper›PMID 30530492›Full record

ArticleThe Journal of biological chemistry2019

Yeast and human P4-ATPases transport glycosphingolipids using conserved structural motifs.

Bartholomew P Roland, Tomoki Naito, Jordan T Best, Cayetana Arnaiz-Yépez, Hiroyuki Takatsu, Roger J Yu, Hye-Won Shin, Todd R Graham

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 82 citations in OpenAlex.

  1. Article
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  3. Review
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  9. Review
  10. Article
  11. Article
  12. Molecular and cellular biology · 2024
    Article
  13. ATP10A deficiency results in male-specific infertility in mice.Frontiers in cell and developmental biology · 2024
    Article
  14. Review
  15. Functional Analysis of the P-Type ATPases Apt2-4 fromJournal of fungi (Basel, Switzerland) · 2023
    Article
  16. Review
  17. Lipid Transport byInfection and immunity · 2022
    Article
  18. Article
  19. Article
  20. Imaging of Lipid Uptake inBio-protocol · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Bartholomew P RolandFrom the Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235 and.ORCID 0000-0002-9033-9942
Tomoki Naitothe Graduate School of Pharmaceutical Science, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
Jordan T BestFrom the Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235 and.
Cayetana Arnaiz-YépezFrom the Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235 and.
Hiroyuki Takatsuthe Graduate School of Pharmaceutical Science, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
Roger J YuFrom the Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235 and.
Hye-Won Shinthe Graduate School of Pharmaceutical Science, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.ORCID 0000-0002-9138-9554
Todd R GrahamFrom the Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235 and tr.graham@vanderbilt.edu.
Vanderbilt University · USKyoto University · JP

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Program in NeurogenomicsT32MH065215 · NIMH · VANDERBILT UNIVERSITY · PI ROGER J COLBRAN · 2002 to 2026
$6.4M
P4-ATPase mechanism of phospholipid translocationR01GM107978 · NIGMS · VANDERBILT UNIVERSITY · PI GRAHAM, TODD R · 2013 to 2021
$2.5M
Molecular Characterization of the Phospholipid Flippase Substrate PathwayF32GM116310 · NIGMS · VANDERBILT UNIVERSITY · PI ROLAND, BARTHOLOMEW P · 2015 to 2016
$109k
NCI NIH HHS P30 CA068485NIDDK NIH HHS P30 DK058404NIGMS NIH HHS F32 GM116310NIGMS NIH HHS R01 GM107978NIMH NIH HHS T32 MH065215
6 · The paper itself

Abstract

Lipid transport is an essential process with manifest importance to human health and disease. Phospholipid flippases (P4-ATPases) transport lipids across the membrane bilayer and are involved in signal transduction, cell division, and vesicular transport. Mutations in flippase genes cause or contribute to a host of diseases, such as cholestasis, neurological deficits, immunological dysfunction, and metabolic disorders. Genome-wide association studies have shown that

Indexed as

Models, MolecularAdenosine TriphosphatasesATP-Binding Cassette TransportersBiological Transport, ActiveGlucosylceramidesHeLa CellsHumansMembrane Transport ProteinsMutagenesis, Site-DirectedProtein DomainsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSchizosaccharomycesSchizosaccharomyces pombe ProteinsAdenosine TriphosphatasesATP10A protein, humanATP-Binding Cassette TransportersDnf1 protein, S cerevisiaeDnf2 protein, S cerevisiaeGlucosylceramidesMembrane Transport ProteinsSaccharomyces cerevisiae ProteinsSchizosaccharomyces pombe Proteinscerebrosideenzyme mechanismflippaseglucosylceramideglycolipidglycosphingolipidslipid transportmembrane asymmetrymembrane bilayermembrane biologyP4-ATPasesphingolipid

Identifiers

PMID30530492
PMCPMC6369285
OpenAlexW2904365419

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.