Evidence map›Paper›PMID 30530491›Full record

ArticleThe Journal of biological chemistry2019

The yeast copper chaperone for copper-zinc superoxide dismutase (CCS1) is a multifunctional chaperone promoting all levels of SOD1 maturation.

Stefanie D Boyd, Jenifer S Calvo, Li Liu, Morgan S Ullrich, Amélie Skopp, Gabriele Meloni, Duane D Winkler

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. From hemocuprein to CSRP: the many faces of Cu/Zn superoxide dismutase.Metallomics : integrated biometal science · 2026
    Review
  5. Review
  6. Cuproptosis-associated genesFrontiers in immunology · 2026
    Article
  7. Article
  8. Copper homeostasis and cuproptosis in Alzheimer's disease (Review).International journal of molecular medicine · 2025
    Review
  9. Article
  10. Review
  11. Structural insights into the role of reduced cysteine residues in SOD1 amyloid filament formation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Review
  13. Review
  14. Pathogenic RBiochemistry · 2024
    Article
  15. Review
  16. Review
  17. Role of copper and its complexes in cardiovascular diseases.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Stefanie D BoydFrom the Departments of Biological Sciences and.
Jenifer S CalvoChemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas 75080.ORCID 0000-0002-0938-2602
Li LiuFrom the Departments of Biological Sciences and.
Morgan S UllrichFrom the Departments of Biological Sciences and.
Amélie SkoppFrom the Departments of Biological Sciences and.
Gabriele MeloniChemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas 75080.ORCID 0000-0003-4976-1401
Duane D WinklerFrom the Departments of Biological Sciences and duane.winkler@utdallas.edu.ORCID 0000-0003-1045-0323
The University of Texas at Dallas · US

Funding

Principles of selectivity and translocation in transition metal transporters, metallochaperones, and associated metalloproteinsR35GM128704 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI Gabriele Meloni · 2018 to 2026
$3.5M
Molecular Mechanisms of Sod1 Maturation ProcessesR01GM120252 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI WINKLER, DUANE DAVID · 2016 to 2020
$1.3M
Effects of dietary agents on lysosomes in mucolipidosisR21AT001935 · NCCIH · BRIGHAM AND WOMEN'S HOSPITAL · PI VASSILEV, PETER M · 2004 to 2005
$425k
NCCIH NIH HHS R21 AT001935NIGMS NIH HHS R01 GM120252NIGMS NIH HHS R35 GM128704
6 · The paper itself

Abstract

Copper (Cu) is essential for the survival of aerobic organisms through its interaction with molecular oxygen (O

Indexed as

Catalytic DomainCopperDisulfidesMolecular ChaperonesProtein BindingSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSuperoxide Dismutase-1CopperDisulfidesMolecular ChaperonesSaccharomyces cerevisiae ProteinsSuperoxide Dismutase-1CCS1chaperonecopper transportcopper-zinc superoxide dismutase (SOD1)dual chaperoneenzyme maturationmetal ion-protein interactionmetallo-chaperonemetallo-proteinmultifunctional enzymeoxidative stresspost-translational modification (PTM)protein complexsuperoxide dismutase (SOD)

Identifiers

PMID30530491
PMCPMC6369272
OpenAlexW2903653109

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.