Evidence map›Paper›PMID 30530238›Full record

SynthesisDrug and alcohol dependence2019

Systematic review of outcome domains and measures used in psychosocial and pharmacological treatment trials for cannabis use disorder.

Dustin C Lee, Nicolas J Schlienz, Erica N Peters, Robert H Dworkin, Dennis C Turk, Eric C Strain, Ryan Vandrey

Open access · greenAbstract readSystematic Review
In one paragraph

Synthesis in Drug and alcohol dependence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 46 citations in OpenAlex.

  1. Characterizing cannabis use reduction and change in functioning during treatment: Initial steps on the path to new clinical endpoints.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2022
    Trial
  2. Evaluating cannabis use risk reduction as an alternative clinical outcome for cannabis use disorder.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2022
    Trial
  3. Trial
  4. Article
  5. Pharmacotherapy for Cannabis Use Disorder: Preclinical and Clinical Models.Current topics in behavioral neurosciences · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Assessing Cannabis Use in People with Psychosis.Cannabis and cannabinoid research · 2024
    Review
  10. Article
  11. Is it time for a cannabis harm reduction approach? Commentary on Sherman et al. (2022) and Borodovsky et al. (2022).Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Associations of mode of administration on cannabis consumption and subjective intoxication in daily life.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2022
    Article
  17. Article
  18. 3-Year Follow-up of Lower Risk Cannabis Use Patterns: Evidence from a Longitudinal Survey.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Dustin C LeeBehavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: dlee214@jhmi.edu.
Nicolas J SchlienzBehavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Erica N PetersBattelle Public Health Center for Tobacco Research, Battelle Memorial Institute, Baltimore, MD, USA.
Robert H DworkinDepartment of Anesthesiology, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA.
Dennis C TurkDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.
Eric C StrainBehavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Ryan VandreyBehavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · USBattelle · USUniversity of Rochester · USUniversity of Washington · US

Funding

HUMAN BEHAVIORAL PHARMACOLOGY OF SUBSTANCE ABUSET32DA007209 · NIDA · JOHNS HOPKINS UNIVERSITY · PI Eric C. Strain, Elise M Weerts · 1985 to 2026
$12.9M
Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) Public-Private PartnershipU01FD005936 · FDA · UNIVERSITY OF ROCHESTER · PI DWORKIN, ROBERT H · 2016 to 2020
$2.5M
Analgesic Clinical Trial Innovations,Opportunities,and Networks(ACTION)U01FD004187 · FDA · UNIVERSITY OF ROCHESTER · PI DWORKIN, ROBERT H · 2011 to 2014
$1.8M
FDA HHS U01 FD004187FDA HHS U01 FD005936NIDA NIH HHS T32 DA007209
6 · The paper itself

Abstract

Cannabis use disorder (CUD) is prevalent and demand for treatment is increasing, yet few individuals engage in formal treatment and the efficacy of established interventions for CUD is modest. Existing clinical trials evaluating psychosocial and pharmacological treatments for CUD have incorporated a wide variety of measures for assessing cannabis use outcomes, including abstinence, self-reported frequency and quantity used, withdrawal, use/dependence severity, and other psychosocial outcomes. The heterogeneity of measures and outcomes has limited quantitative analyses of the comparative effectiveness of existing interventions. The purpose of this systematic review is to: 1) identify and characterize approaches for measuring cannabis use in existing CUD intervention trials, including abstinence, frequency and quantity of use, and 2) summarize measures used to assess treatment efficacy in other outcome domains (e.g., cannabis use severity, psychosocial functioning, cannabis withdrawal), and provide a platform for future research to evaluate which outcome measures are most likely to reflect treatment efficacy and clinically significant improvement in other outcome domains.

Indexed as

CannabisHumansMarijuana AbuseSelf ReportSubstance Withdrawal SyndromeTreatment OutcomeAbuseCannabis use disorderDependenceOutcomesRandomized controlled trialTreatment

Identifiers

PMID30530238
PMCPMC7038155
OpenAlexW2901635649

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.