Evidence map›Paper›PMID 30530175›Full record

ReviewCurrent opinion in microbiology2018

Effective models and the search for quantitative principles in microbial evolution.

Benjamin H Good, Oskar Hallatschek

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Dynamics of dN/dS within recombining bacterial populations.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Benjamin H GoodDepartment of Physics, University of California, Berkeley, United States; Department of Bioengineering, University of California, Berkeley, United States. Electronic address: benjamin.h.good@berkeley.edu.
Oskar HallatschekDepartment of Physics, University of California, Berkeley, United States; Department of Integrative Biology, University of California, Berkeley, United States.

Funding

Resolving the Mechano-Chemical Regulation of Microbial Populations in Microfluidic DevicesR01GM115851 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HALLATSCHEK, OSKAR · 2015 to 2023
$2.2M
NIGMS NIH HHS R01 GM115851
6 · The paper itself

Abstract

Microbes evolve rapidly. Yet they do so in idiosyncratic ways, which depend on the specific mutations that are beneficial or deleterious in a given situation. At the same time, some population-level patterns of adaptation are strikingly similar across different microbial systems, suggesting that there may also be simple, quantitative principles that unite these diverse scenarios. We review the search for simple principles in microbial evolution, ranging from the biophysical level to emergent evolutionary dynamics. A key theme has been the use of effective models, which coarse-grain over molecular and cellular details to obtain a simpler description in terms of a few effective parameters. Collectively, these theoretical approaches provide a set of quantitative principles that facilitate understanding, prediction, and potentially control of evolutionary phenomena, though formidable challenges remain due to the ecological complexity of natural populations.

Indexed as

Bacterial Physiological PhenomenaBiological EvolutionModels, BiologicalAdaptation, BiologicalBacteriaEcosystem

Identifiers

PMID30530175
PMCPMC6599682

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.