Evidence map›Paper›PMID 30530064›Full record

ArticleClinical biomechanics (Bristol, Avon)2019

External loads associated with anterior cruciate ligament injuries increase the correlation between tibial slope and ligament strain during in vitro simulations of in vivo landings.

Nathaniel A Bates, Maria C Mejia Jaramillo, Manuela Vargas, April L McPherson, Nathan D Schilaty, Christopher V Nagelli, Aaron J Krych, Timothy E Hewett

Abstract read
In one paragraph

Article in Clinical biomechanics (Bristol, Avon), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Steep tibial slope correlates with inferior patient‑reported knee function independent of tunnel widening.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026
    Article
  2. Does Tibial Plateau Slope and Depth Influence ACL Strain In Vivo?Orthopaedic journal of sports medicine · 2024
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  8. Difference in sex and the effect of a dominant lower extremity in the posterior tibial slope angle in healthy Japanese subjects.Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Nathaniel A BatesMayo Clinic Biomechanics Laboratories, Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA; Sports Medicine Center, Mayo Clinic, Rochester, MN, USA; Department of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. Electronic address: bates.nathaniel@mayo.edu.
Maria C Mejia JaramilloDepartment of Biomedical Engineering, Universidad EIA, Medellin, Colombia.
Manuela VargasDepartment of Biomedical Engineering, Universidad EIA, Medellin, Colombia.
April L McPhersonMayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, USA.
Nathan D SchilatyMayo Clinic Biomechanics Laboratories, Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA; Sports Medicine Center, Mayo Clinic, Rochester, MN, USA; Department of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Christopher V NagelliDepartment of Physical Medicine & Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Aaron J KrychMayo Clinic Biomechanics Laboratories, Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA; Sports Medicine Center, Mayo Clinic, Rochester, MN, USA.
Timothy E HewettMayo Clinic Biomechanics Laboratories, Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA; Sports Medicine Center, Mayo Clinic, Rochester, MN, USA; Department of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN, USA; Department of Physical Medicine & Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Mayo Clinic in Arizona · USMayo Clinic in Florida · USUniversidad de Medellín · CO

Funding

Mayo Clinic Interdisciplinary Women's Health Research ProgramK12HD065987 · NICHD · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL · 2010 to 2023
$6.7M
Neuromuscular Intervention Targeted to Mechanisms of ACL Load in Female AthletesR01AR055563 · NIAMS · OHIO STATE UNIVERSITY · PI BATES, NATHANIEL ANDREW, KRYCH, AARON · 2008 to 2022
$5.9M
Multi-faceted Approach to Modeling ACL Injury MechanismsR01AR056259 · NIAMS · OHIO STATE UNIVERSITY · PI HEWETT, TIMOTHY E · 2009 to 2017
$4.9M
NIAMS NIH HHS L30 AR070273NIAMS NIH HHS R01 AR055563NIAMS NIH HHS R01 AR056259NICHD NIH HHS K12 HD065987
6 · The paper itself

Abstract

backgroundThe aim of the present study was to evaluate the relationship between tibial slope angle and ligament strain during in vitro landing simulations that induce ACL failure through the application of variable external loading at the knee. The hypothesis tested was that steeper posterior tibial slope angle would be associated with higher ACL strain during a simulated landing task across all external loading conditions.

methodsKinetics previously derived from an in vivo cohort performing drop landings were reproduced on 45 cadaveric knees via the mechanical impact simulator. MRIs were taken of each specimen and used to calculate medial compartment posterior tibial slope, lateral compartment posterior tibial slope, and coronal plane tibial slope. Linear regression analyses were performed between these angles and ACL strain to determine whether tibial slope was a predictive factor for ACL strain.

findingsMedial and lateral posterior tibial slope were predictive factors for ACL strain during some landings with higher combined loads. Medial posterior slope was more predictive of ACL strain in most landings for male specimens, while lateral posterior and coronal slope were more predictive in female specimens, but primarily when high abduction moments were applied.

interpretationTibial slope has the potential to influence ACL strain during landing, especially when large abduction moments are present at the knee. Deleterious external loads to the ACL increase the correlation between tibial slope and ACL strain, which indicates that tibial slope angles are an additive factor for athletes apt to generate large out-of-plane knee moments during landing tasks.

Indexed as

AdolescentAdultAnterior Cruciate LigamentAnterior Cruciate Ligament InjuriesAthletesBiomechanical PhenomenaCadaverFemaleHumansIn Vitro TechniquesKneeKnee JointMagnetic Resonance ImagingMaleMiddle AgedStress, MechanicalAnterior cruciate ligamentInjury risk factorsKnee biomechanicsLandingTibial slope

Identifiers

PMID30530064
PMCPMC6448403
OpenAlexW2901098604

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.