Evidence map›Paper›PMID 30529823›Full record

ReviewCurrent opinion in neurobiology2019

Astrocyte identity: evolutionary perspectives on astrocyte functions and heterogeneity.

Yongjie Yang, Rob Jackson

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Shaping the Neocortex: Radial Glia and Astrocytes in Development and Evolution.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  2. Role of astrocytes in the pathogenesis of perinatal brain injury.Molecular medicine (Cambridge, Mass.) · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Astrocyte development-More questions than answers.Frontiers in cell and developmental biology · 2023
    Review
  10. Article
  11. Review
  12. Evolution of astrocytes: From invertebrates to vertebrates.Frontiers in cell and developmental biology · 2022
    Review
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yongjie YangDepartment of Neuroscience, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA, 02111, United States; Sackler School of Biomedical Sciences, Tufts University, 145 Harrison Ave, Boston, MA, 02111, United States. Electronic address: yongjie.yang@tufts.edu.
Rob JacksonDepartment of Neuroscience, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA, 02111, United States; Sackler School of Biomedical Sciences, Tufts University, 145 Harrison Ave, Boston, MA, 02111, United States. Electronic address: rob.jackson@tufts.edu.

Funding

Astrolglia-Mediated Pathogenic Mechanisms in Fragile X Syndrome (FXS)R01MH106490 · NIMH · TUFTS UNIVERSITY BOSTON · PI YANG, YONGJIE · 2016 to 2025
$3.3M
Regulation of Astrocyte Heterogeneity and Developmental Maturation in the CNSR01MH099554 · NIMH · TUFTS UNIVERSITY BOSTON · PI JACKSON, F ROB, YANG, YONGJIE · 2013 to 2017
$2.8M
Glial cell subtypes regulating rhythmic behaviorR21NS107804 · NINDS · TUFTS UNIVERSITY BOSTON · PI JACKSON, F ROB · 2018 to 2019
$454k
NIMH NIH HHS R01 MH099554NIMH NIH HHS R01 MH106490NINDS NIH HHS R21 NS107804
6 · The paper itself

Abstract

The development of new animal models, in vivo isolation approaches, and improvements in genome-wide RNA expression methods have greatly propelled molecular profiling of astrocytes and the characterization of astrocyte heterogeneity in the central nervous system (CNS). Several recent reviews have comprehensively discussed the molecular and functional diversity of mammalian astrocytes. In this brief review, we emphasize interspecies comparisons and an evolutionary perspective regarding the astro(glia) of vertebrates and invertebrates which are similar in form and function. This analysis has revealed conserved astrocyte transcriptomes in the fly, mouse and human. We also offer opinions about the pattern and origin of astrocyte heterogeneity in the CNS.

Indexed as

AstrocytesCentral Nervous SystemAnimalsHumansModels, Animal

Identifiers

PMID30529823
PMCPMC6551291

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.