Evidence map›Paper›PMID 30529759›Full record

ArticleCellular signalling2019

A non-canonical JAGGED1 signal to JAK2 mediates osteoblast commitment in cranial neural crest cells.

Archana Kamalakar, Melissa S Oh, Yvonne C Stephenson, Samir A Ballestas-Naissir, Michael E Davis, Nick J Willett, Hicham M Drissi, Steven L Goudy

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular signalling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Archana KamalakarDepartment of Otolaryngology, Emory University, Atlanta, GA, USA. Electronic address: archana.kamalakar@emory.edu.
Melissa S OhDepartment of Otolaryngology, Emory University, Atlanta, GA, USA. Electronic address: melissa.oh@emory.edu.
Yvonne C StephensonDepartment of Otolaryngology, Emory University, Atlanta, GA, USA. Electronic address: yvonne.stephenson@emory.edu.
Samir A Ballestas-NaissirDepartment of Otolaryngology, Emory University, Atlanta, GA, USA. Electronic address: samir.ballestas.naissir@emory.edu.
Michael E DavisWallace H. Coulter Department of Biomedical Engineering, Georgia Tech College of Engineering, Atlanta, GA, USA. Electronic address: michael.davis@bme.gatech.edu.
Nick J WillettDepartment of Orthopaedics, Emory University, Atlanta, GA, USA; The Atlanta Veterans Affairs Medical Center, Atlanta, GA, USA. Electronic address: nick.james.willett@emory.edu.
Hicham M DrissiDepartment of Cell biology, Emory University, Atlanta, GA, USA; Department of Orthopaedics, Emory University, Atlanta, GA, USA; The Atlanta Veterans Affairs Medical Center, Atlanta, GA, USA. Electronic address: hicham.drissi@emory.edu.
Steven L GoudyDepartment of Otolaryngology, Emory University, Atlanta, GA, USA. Electronic address: steven.goudy@emory.edu.
Emory University · USThe Wallace H. Coulter Department of Biomedical Engineering · US

Funding

PEG hydrogels for progenitor cell deliveryR01HL127236 · NHLBI · EMORY UNIVERSITY · PI DAVIS, MICHAEL E · 2016 to 2019
$1.8M
Targeted Regenerative Therapy to Treating Pediatric Maxillary Bone DeficiencyR56DE026762 · NIDCR · EMORY UNIVERSITY · PI GOUDY, STEVEN L · 2018 to 2018
$390k
NHLBI NIH HHS R01 HL127236NIDCR NIH HHS R56 DE026762
6 · The paper itself

Abstract

During craniofacial development, cranial neural crest (CNC) cells migrate into the developing face and form bone through intramembranous ossification. Loss of JAGGED1 (JAG1) signaling in the CNC cells is associated with maxillary hypoplasia or maxillary bone deficiency (MBD) in mice and recapitulates the MBD seen in humans with Alagille syndrome. JAGGED1, a membrane-bound NOTCH ligand, is required for normal craniofacial development, and Jagged1 mutations in humans are known to cause Alagille Syndrome, which is associated with cardiac, biliary, and bone phenotypes and these children experience increased bony fractures. Previously, we demonstrated deficient maxillary osteogenesis in Wnt1-cre;Jagged1

Indexed as

Jagged-1 ProteinNeural CrestOsteoblastsAnimalsCalcification, PhysiologicCells, CulturedJanus Kinase 2Maxillofacial DevelopmentMiceOsteogenesisJag1 protein, mouseJagged-1 ProteinJak2 protein, mouseJanus Kinase 2JAK2Maxillary bone diseaseMaxillary developmentNon-canonical JAGGED1 signalingOsteoblast commitment

Identifiers

PMID30529759
PMCPMC6420215
OpenAlexW2890468712

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.