ArticlePsychoneuroendocrinology2019
Resting amygdala connectivity and basal sympathetic tone as markers of chronic hypervigilance.
Article in Psychoneuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- The convergent neuroscience of Christian prayer and attachment relationships in the context of mental health: a systematic review.Frontiers in psychology · 2025Pooled it
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- Symptom network connectivity in PTSD comorbid with depression in bereaved Chinese parents who have lost their only child.BMC psychiatry · 2025Article
- Hypervigilance strikes a balance between external and internal attention: behavioral and modeling evidence from the switching attention task.Psychological research · 2024Article
- The Dichotomy of Threat and Deprivation as Subtypes of Childhood Maltreatment: Differential Functional Connectivity Patterns of Threat and Reward Circuits in an Adult Trauma Sample.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Stressor-Specific Sex Differences in Amygdala-Frontal Cortex Networks.Journal of clinical medicine · 2023Article
- How past trauma impacts emotional intelligence: Examining the connection.Frontiers in psychology · 2023Review
- Psychological impacts of the COVID-19 pandemic on one-month postpartum mothers in a metropolitan area of Japan.BMC pregnancy and childbirth · 2021Article
- Collective Trauma and Mental Health in Adolescents: A Retrospective Cohort Study of the Effects of Retraumatization.Frontiers in psychiatry · 2021Article
- Neural Correlates of Facial Expression Recognition in Earthquake Witnesses.Frontiers in neuroscience · 2019Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundChronic hypervigilance, a state of sustained alertness and hyperarousal in the absence of threat, has been shown to predict poorer clinical outcomes post-trauma. An exaggerated and persistent amygdala alerting response to affective information has been proposed as a reactivity-based, and thus indirect, marker of hypervigilance. However, because chronic hypervigilance is a persistent rather than reactive state, it should be directly observable under resting-state conditions without the need for exposure to affectively charged stimuli.
objectiveWe tested resting amygdala connectivity and basal sympathetic and hypothalamic-pituitary-adrenal axis activity as direct neural and neuroendocrine markers of chronic hypervigilance.
participants24 trauma-exposed women (age M = 22.9, SD = 5.5) and 20 no-trauma controls (age M = 21.1, SD = 3.2). MEASURES: Amygdala connectivity was measured using functional magnetic resonance imaging at rest and during viewing of novel and familiar affective scenes. Elevated amygdala connectivity during the viewing of novel scenes (exaggerated alerting response) and familiar scenes (persistent alerting response) was used as a reactivity-based index of hypervigilance. Resting amygdala connectivity and basal salivary alpha-amylase (sAA) and cortisol were tested as neural and neuroendocrine markers of hypervigilance, respectively.
resultsCompared to no-trauma controls, trauma-exposed women showed greater connectivity between the left amygdala and the ventral anterior cingulate cortex (vACC) both during affective processing and at rest. Exaggerated neural novelty response was associated with greater resting left amygdala-vACC connectivity and higher basal sAA, but not cortisol.
conclusionsGreater synchronization of threat-detection circuitry in the absence of threat and basal sympathetic tone might serve as complementary resting-state markers of the cognitive and physiological components of chronic hypervigilance, respectively.
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