Evidence map›Paper›PMID 30529401›Full record

ArticleBehavioural brain research2019

Moderate prenatal alcohol exposure impairs performance by adult male rats in an object-place paired-associate task.

Lilliana M Sanchez, Jonathan Goss, Jennifer Wagner, Suzy Davies, Daniel D Savage, Derek A Hamilton, Benjamin J Clark

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioural brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lilliana M SanchezDepartment of Psychology, University of New Mexico, Albuquerque, NM, United States.
Jonathan GossDepartment of Psychology, University of New Mexico, Albuquerque, NM, United States.
Jennifer WagnerDepartment of Neurosciences, University of New Mexico, Albuquerque, NM, United States.
Suzy DaviesDepartment of Neurosciences, University of New Mexico, Albuquerque, NM, United States.
Daniel D SavageDepartment of Psychology, University of New Mexico, Albuquerque, NM, United States; Department of Neurosciences, University of New Mexico, Albuquerque, NM, United States.
Derek A HamiltonDepartment of Psychology, University of New Mexico, Albuquerque, NM, United States; Department of Neurosciences, University of New Mexico, Albuquerque, NM, United States.
Benjamin J ClarkDepartment of Psychology, University of New Mexico, Albuquerque, NM, United States. Electronic address: bnjclark@unm.edu.

Funding

Understanding neurophysiological deficits in response inhibition in children with FASDP50AA022534 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Carlos Fernando Valenzuela · 2014 to 2026
$21.5M
Prenatal Alcohol Exposure and Neural Representations of SpaceR21AA024983 · NIAAA · UNIVERSITY OF NEW MEXICO · PI CLARK, BENJAMIN J, HAMILTON, DEREK A. · 2017 to 2018
$398k
NIAAA NIH HHS P50 AA022534NIAAA NIH HHS R21 AA024983
6 · The paper itself

Abstract

Memory impairments, including spatial and object processing, are often observed in individuals with Fetal Alcohol Spectrum Disorders. The neurobiological basis of memory deficits after prenatal alcohol exposure (PAE) is often linked to structural and functional alterations in the medial temporal lobe, including the hippocampus. Recent evidence suggests that the medial temporal lobe plays a critical role in processing high-order sensory stimuli such as complex objects and their associated locations in space. In the first experiment, we tested male rat offspring with moderate PAE in a medial temporal-dependent object-place paired-associate (OPPA) task. The OPPA task requires a conditional discrimination between an identical pair of objects presented at two spatial locations 180° opposite arms of a radial arm maze. Food reinforcement is contingent upon selecting the correct object of the pair for a given spatial location. Adult rats were given a total of 10 trials per day over 14 consecutive days of training. PAE male rats made significantly more errors than male saccharin (SACC) control rats during acquisition of the OPPA task. In Experiment 2, rats performed an object-discrimination task in which a pair of objects were presented in a single arm of the maze. Moderate PAE and SACC control rats exhibited comparable performance. The results suggest that moderate PAE rats can learn to discriminate objects, but are impaired when required to discriminate between objects on the basis of spatial location in the environment.

Indexed as

Analysis of VarianceAnimalsDiscrimination, PsychologicalDisease Models, AnimalEthanolFemaleMaleMemory DisordersPaired-Associate LearningPregnancyPrenatal Exposure Delayed EffectsRatsRats, Long-EvansRecognition, PsychologySaccharinSpatial BehaviorEthanolSaccharinEntorhinalFetal alcoholMedial temporalObject recognitionPerirhinalSpatial behavior

Identifiers

PMID30529401
PMCPMC6324964

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.