Evidence map›Paper›PMID 30529244›Full record

Trial reportAddictive behaviors2019

Concurrent treatment of substance use disorders and PTSD using prolonged exposure: A randomized clinical trial in military veterans.

Sudie E Back, Therese Killeen, Christal L Badour, Julianne C Flanagan, Nicholas P Allan, Elizabeth Santa Ana, Brian Lozano, Kristina J Korte, Edna B Foa, Kathleen T Brady

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Addictive behaviors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 93 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 8 pooled it
16.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01338506 nacompletednot on this map

Integrated Treatment of Operation Enduring Freedom/Operation Iraqi Freedom Veterans With Post-traumatic Stress Disorder and Substance Use Disorders

TypeinterventionalSponsorMedical University of South CarolinaRan2011 to 2016Enrolled81ConditionsPosttraumatic Stress Disorders, Combat Disorders, Alcohol Dependence, Drug DependenceArmsConcurrent Treatment with Prolonged Exposure (COPE)
NCT04760418 nacompletednot on this mapstarted 2021, after this paper: background citation

Evaluating the Impact of Trauma, Trauma-Focused Therapy Services, and COVID-19 Among Patients in the University of Kentucky SMART Clinic

TypeinterventionalSponsorChristal L BadourRan2021 to 2022Enrolled21ConditionsPTSD, Opioid-use Disorder, Substance Use DisordersArmsConcurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure (COPE)
3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 8 syntheses or guidelines pooled it, 196 citations in OpenAlex.

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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Sudie E BackDepartment of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA; Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, USA. Electronic address: backs@musc.edu.
Therese KilleenDepartment of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.
Christal L BadourDepartment of Psychology, University of Kentucky, Lexington, KY, USA.
Julianne C FlanaganDepartment of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.
Nicholas P AllanDepartment of Psychology, Ohio University, Athens, OH, USA.
Elizabeth Santa AnaDepartment of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA; Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, USA.
Brian LozanoDepartment of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA; Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, USA.
Kristina J KortePsychiatry Department, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Edna B FoaDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Kathleen T BradyDepartment of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA; Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, USA.
Medical University of South Carolina · USRalph H. Johnson VA Medical Center · USMassachusetts General Hospital · USOhio University · USUniversity of Kentucky · USUniversity of Pennsylvania · US

Funding

Integrated Treatment of OEF/OIF Veterans with PTSD and Substance Use DisordersR01DA030143 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BACK, SUDIE E · 2010 to 2014
$1.6M
Integrating Neurobiology and Neuroimaging into Research on Addiction and PTSDK02DA039229 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BACK, SUDIE E · 2015 to 2019
$779k
NIDA NIH HHS K02 DA039229NIDA NIH HHS R01 DA030143
6 · The paper itself

Abstract

objectiveA substantial amount of individuals with substance use disorders (SUD) also meet criteria for posttraumatic stress disorder (PTSD). Prolonged Exposure (PE) is an effective, evidence-based treatment for PTSD, but there is limited data on its use among individuals with current alcohol or drug use disorders. This study evaluated the efficacy of an integrated treatment that incorporates PE (Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure or COPE) among veterans.

methodMilitary veterans (N = 81, 90.1% male) with current SUD and PTSD were randomized to 12 sessions of COPE or Relapse Prevention (RP). Primary outcomes included the Clinician Administered PTSD Scale (CAPS), PTSD Checklist-Military version (PCL-M), and the Timeline Follow-back (TLFB).

resultsOn average, participants attended 8 out of 12 sessions and there were no group differences in retention. Intent-to-treat analyses revealed that COPE, in comparison to RP, resulted in significantly greater reductions in CAPS (d = 1.4, p < .001) and PCL-M scores (d = 1.3, p = .01), as well as higher rates of PTSD diagnostic remission (OR = 5.3, p < .01). Both groups evidenced significant and comparable reductions in SUD severity during treatment. At 6-months follow-up, participants in COPE evidenced significantly fewer drinks per drinking day than participants in RP (p = .05).

conclusionsThis study is the first to report on the use of an integrated, exposure-based treatment for co-occurring SUD and PTSD in a veteran sample. The findings demonstrate that integrated, exposure-based treatments are feasible and effective for military veterans with SUD and PTSD. Implications for clinical practice are discussed.

Indexed as

AdultFemaleHumansImplosive TherapyMaleMilitary PersonnelSecondary PreventionStress Disorders, Post-TraumaticSubstance-Related DisordersTreatment OutcomeAddictionPosttraumatic stress disorderProlonged exposurePTSDSubstance use disorderVeterans

Identifiers

PMID30529244
PMCPMC6488423
OpenAlexW2902699783

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.