Evidence map›Paper›PMID 30529190›Full record

ReviewCurrent opinion in immunology2019

Innate lymphoid cell sensing of tissue vitality.

Alexander David Barrow, Marco Colonna

Abstract readReview
In one paragraph

Review in Current opinion in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. CD44 in Group 1 Innate Lymphoid Cells Impacts the Development and Progression of Steatohepatitis.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Uterine Natural Killer Cells.Frontiers in immunology · 2019
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alexander David BarrowDepartment of Microbiology and Immunology, The University of Melbourne and The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia. Electronic address: alexanderdav@unimelb.edu.au.
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, United States. Electronic address: mcolonna@wustl.edu.

Funding

CIS-REGULATORY CIRCUITS FOR ILC FUNCTION AND PLASTICITYR01AI134035 · NIAID · WASHINGTON UNIVERSITY · PI MARCO COLONNA, Eugene M Oltz · 2018 to 2026
$4.8M
The role of TGFbeta in development and function of salivary gland innate lymphoid cellsR01DE025884 · NIDCR · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, WEISMAN, GARY ANDREW · 2017 to 2021
$3.5M
CRTAM-CADM1 INTERACTION IN THE BIOLOGY OF GUT LYMPHOCYTESR01DK103039 · NIDDK · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2015 to 2018
$1.4M
CHROMATIN-BASED DISCOVERY OF ILC GENE REGULATORY CIRCUITSR21AI120606 · NIAID · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, OLTZ, EUGENE M · 2015 to 2016
$419k
NIAID NIH HHS R01 AI134035NIAID NIH HHS R21 AI120606NIDCR NIH HHS R01 DE025884NIDDK NIH HHS R01 DK103039
6 · The paper itself

Abstract

Innate lymphoid cells (ILCs) constitute a heterogeneous population of cytokine-secreting cells that colonize different tissues and are heavily reliant on cytokines and other secreted factors for their development, maintenance and effector functions. Most ILCs are tissue resident and differentiate in non-lymphoid peripheral tissues. As tissue-resident sentinels, ILCs must rapidly identify pathogens or malignancy in an effort to return the tissue to homeostasis. Here we review the mechanisms that ILCs employ to sense cytokines and other potent immunoregulatory factors that promote their development in different tissues as well as the ability to distinguish pathogenic versus healthy tissue microenvironments and highlight the importance of these pathways for human disease.

Indexed as

Immunity, InnateAnimalsAntigens, NeoplasmApoptosisCellular MicroenvironmentHomeostasisHost-Pathogen InteractionsHumansLymphocytesPathogen-Associated Molecular Pattern MoleculesAntigens, NeoplasmPathogen-Associated Molecular Pattern Molecules

Identifiers

PMID30529190
PMCPMC6469350

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.