Evidence map›Paper›PMID 30529168›Full record

ArticleAlcohol (Fayetteville, N.Y.)2020

Sexually divergent changes in select brain proteins and neurosteroid levels after a history of ethanol drinking and intermittent PTSD-like stress exposure in adult C57BL/6J mice.

Leslie L Devaud, Mehrdad Alavi, Jeremiah P Jensen, Melinda L Helms, Michelle A Nipper, Deborah A Finn

Open access · greenAbstract read
In one paragraph

Article in Alcohol (Fayetteville, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Leslie L DevaudSchool of Pharmacy, Pacific University, Hillsboro, OR, United States.
Mehrdad AlaviSchool of Pharmacy, Pacific University, Hillsboro, OR, United States.
Jeremiah P JensenDepartment of Behavioral Neuroscience, Oregon Health & Sciences University, Portland, OR, United States.
Melinda L HelmsDepartment of Behavioral Neuroscience, Oregon Health & Sciences University, Portland, OR, United States.
Michelle A NipperDepartment of Behavioral Neuroscience, Oregon Health & Sciences University, Portland, OR, United States.
Deborah A FinnDepartment of Behavioral Neuroscience, Oregon Health & Sciences University, Portland, OR, United States; Veterans Administration Portland Health Care System, Portland, OR, United States. Electronic address: finnd@ohsu.edu.
Oregon Health & Science University · USPacific University Oregon · US

Funding

NEUROSTEROID MODULATION OF ETHANOL WITHDRAWAL SEVERITYR01AA012439 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI FINN, DEBORAH A., ROSSI, DAVID J · 2000 to 2017
$4.6M
Adolescent Binge Drinking Increases Adult Alcohol Intake: Glutamate MechanismsI01BX001070 · VA · PORTLAND VA MEDICAL CENTER · PI FINN, DEBORAH A. · 2011 to 2014
–
Traumatic stress and binge drinking as risk factors for excessive alcohol intakeI01BX002966 · VA · PORTLAND VA MEDICAL CENTER · PI FINN, DEBORAH A. · 2015 to 2023
–
BLRD VA I01 BX001070BLRD VA I01 BX002966NIAAA NIH HHS R01 AA012439
6 · The paper itself

Abstract

Human studies reported that the number of past-year stressors was positively related to current drinking patterns, including binge drinking. In animal models, exposure to predator odor stress (PS), considered a model of traumatic stress, consistently increased ethanol intake. Recently, we reported that repeated PS significantly increased ethanol intake and had a synergistic interaction with prior binge drinking (binge group) in male but not in female C57BL/6J mice, when compared to mice without prior binge exposure (control group). The current studies utilized plasma and dissected prefrontal cortex (PFC) and hippocampal tissue from these animals and from age-matched naïve mice (naïve group). Western blots assessed relative protein levels of P450scc (an enzyme involved in the first step of steroidogenesis), of GABA

Indexed as

Brain ChemistryAlcohol DrinkingAnimalsFemaleHippocampusMaleMiceMice, Inbred C57BLNerve Tissue ProteinsNeurosteroidsPrefrontal CortexSex FactorsStress Disorders, Post-TraumaticNerve Tissue ProteinsNeurosteroidsGABA(A) receptorsHippocampusNeuroactive steroidsPredator odorPrefrontal cortexSynaptic plasticity

Identifiers

PMID30529168
PMCPMC7061734
OpenAlexW2904376204

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.