Evidence map›Paper›PMID 30529114›Full record

ArticlePharmacology, biochemistry, and behavior2019

DID it or DIDn't it? Exploration of a failure to replicate binge-like alcohol-drinking in C57BL/6J mice.

Karen K Szumlinski, Michal A Coelho, Kaziya M Lee, Tori Tran, Kimberly R Sern, Alexandria Bernal, Tod E Kippin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology, biochemistry, and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  4. Article
  5. Animal Models of Excessive Alcohol Consumption in Rodents.Current topics in behavioral neurosciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Karen K SzumlinskiDepartment of Psychological and Brain Sciences, University of California at Santa Barbara, Santa Barbara, CA, USA; Department of Molecular, Developmental and Cell Biology and the Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA, USA. Electronic address: karen.szumlinski@psych.ucsb.edu.
Michal A CoelhoDepartment of Psychological and Brain Sciences, University of California at Santa Barbara, Santa Barbara, CA, USA.
Kaziya M LeeDepartment of Psychological and Brain Sciences, University of California at Santa Barbara, Santa Barbara, CA, USA.
Tori TranDepartment of Psychological and Brain Sciences, University of California at Santa Barbara, Santa Barbara, CA, USA.
Kimberly R SernDepartment of Psychological and Brain Sciences, University of California at Santa Barbara, Santa Barbara, CA, USA.
Alexandria BernalDepartment of Psychological and Brain Sciences, University of California at Santa Barbara, Santa Barbara, CA, USA.
Tod E KippinDepartment of Psychological and Brain Sciences, University of California at Santa Barbara, Santa Barbara, CA, USA; Department of Molecular, Developmental and Cell Biology and the Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA, USA; Institute for Collaborative Biotechnology, University of California at Santa Barbara, Santa Barbara, CA, USA.
University of California, Santa Barbara · US

Funding

Adolescent Alcohol and AnxietyR01AA024044 · NIAAA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI SZUMLINSKI, KAREN KATHLEEN · 2016 to 2020
$1.7M
NIAAA NIH HHS R01 AA024044
6 · The paper itself

Abstract

We previously reported that commercially-sourced C57BL/6J (B6) male mice with a history of adult-onset binge-drinking exhibit anxiety-like behavior in early withdrawal, while the negative affective state incubates during protracted withdrawal in adolescent-onset binge-drinking males. As the results of such studies are potentially confounded by age-related differences in reactivity to environmental stress, we employed a 2-bottle-choice DID procedure (20 and 40% alcohol; 20 min habituation to the drinking cage) to examine the effects of binge-drinking on negative affect in male and female, adult and adolescent, B6 mice from our university colony. Unexpectedly, the mice in the initial experiment exhibited very low alcohol intake, with little sign of withdrawal-induced negative affect. This failure to replicate prompted us to examine how the duration of drinking cage habituation, the number of alcohol concentrations presented and the animal source might influence the propensity to binge-drink. Herein, we show that both male and female adult mice from our colony will binge-drink when allowed 45 min to habituate to the drinking cages, irrespective of whether mice are offered a choice between 2, 3 or 4 alcohol concentrations. Further, when drinking under 4-bottle-choice procedures (5, 10, 20 and 40% alcohol), adult-onset binge-drinking females exhibit robust negative affect in early withdrawal akin to that reported previously for adult males; however, the negative affective state persists for at least 30 days into withdrawal. Also unlike males, adolescent-onset binge-drinking females exhibit some signs of negative affect, as well as potentiated alcohol intake, in early withdrawal, which persist into later withdrawal. These latter data suggest that the age-related differences in the temporal patterning of the negative affective state produced by alcohol withdrawal may vary as a function of sex, which may have implications for understanding sex differences in the etiology of affective disorders and alcoholism co-morbidity.

Indexed as

Disease Models, AnimalAge FactorsAlcoholismAnimalsAnxietyBehavior, AnimalBehavior Rating ScaleBinge DrinkingEthanolFemaleFollow-Up StudiesMaleMiceMice, Inbred C57BLPhotoperiodSex FactorsEthanolAdolescenceAlcoholismAnimal modelAnxietyBinge-drinkingDepressionDrinking-in-the-DarkSex differences

Identifiers

PMID30529114
PMCPMC6380954
OpenAlexW2903622567

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.