Evidence map›Paper›PMID 30529033›Full record

ArticleJournal of molecular biology2019

A Molecular Target for an Alcohol Chain-Length Cutoff.

Hae-Won Chung, E Nicholas Petersen, Cerrone Cabanos, Keith R Murphy, Mahmud Arif Pavel, Andrew S Hansen, William W Ja, Scott B Hansen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Sex-specific lipid dysregulation in theBrain communications · 2022
    Article
  7. Current View on the Mechanisms of Alcohol-Mediated Toxicity.International journal of molecular sciences · 2021
    Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Hae-Won ChungDepartment of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA; Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
E Nicholas PetersenDepartment of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA; Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Cerrone CabanosDepartment of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA; Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Keith R MurphyDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA; Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA; Program in Integrative Biology and Neuroscience, Florida Atlantic University, Jupiter, FL 33458, USA.
Mahmud Arif PavelDepartment of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA; Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Andrew S HansenHBBiotech, BioInnovations Gateway, Salt Lake City, UT 84115, USA.
William W JaDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA; Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA.
Scott B HansenDepartment of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA; Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA. Electronic address: shansen@scripps.edu.
Scripps Research Institute · US

Funding

Molecular Mechanism of MechanosensationDP2NS087943 · NINDS · SCRIPPS FLORIDA · PI HANSEN, SCOTT B · 2013 to 2013
$2.8M
Nutritional and Epigenetic Priming of Metabolism and Aging in DrosophilaR01AG045036 · NIA · SCRIPPS FLORIDA · PI JA, WILLIAM W · 2014 to 2018
$2.0M
NIA NIH HHS R01 AG045036NINDS NIH HHS DP2 NS087943
6 · The paper itself

Abstract

Despite the widespread consumption of ethanol, mechanisms underlying its anesthetic effects remain uncertain. n-Alcohols induce anesthesia up to a specific chain length and then lose potency-an observation known as the "chain-length cutoff effect." This cutoff effect is thought to be mediated by alcohol binding sites on proteins such as ion channels, but where these sites are for long-chain alcohols and how they mediate a cutoff remain poorly defined. In animals, the enzyme phospholipase D (PLD) has been shown to generate alcohol metabolites (e.g., phosphatidylethanol) with a cutoff, but no phenotype has been shown connecting PLD to an anesthetic effect. Here we show loss of PLD blocks ethanol-mediated hyperactivity in Drosophila melanogaster (fruit fly), demonstrating that PLD mediates behavioral responses to alcohol in vivo. Furthermore, the metabolite phosphatidylethanol directly competes for the endogenous PLD product phosphatidic acid at lipid-binding sites within potassium channels [e.g., TWIK-related K

Indexed as

AnimalsBinding SitesCells, CulturedDrosophila melanogasterDrosophila ProteinsEthanolGlycerophospholipidsPhosphatidic AcidsPhospholipase DPotassium Channels, Tandem Pore DomainRNA-Binding ProteinsCuff protein, DrosophilaDrosophila ProteinsEthanolGlycerophospholipidsPhosphatidic AcidsphosphatidylethanolPhospholipase Dpotassium channel protein TREK-1Potassium Channels, Tandem Pore DomainRNA-Binding Proteinsethanolion channellipidsmetabolitephospholipase

Identifiers

PMID30529033
PMCPMC6360937
OpenAlexW2902894675

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.