Evidence map›Paper›PMID 30528902›Full record

ArticleiScience2018

MicroRNA-124 Regulates Fatty Acid and Triglyceride Homeostasis.

Tyler A Shaw, Ragunath Singaravelu, Megan H Powdrill, Jordan Nhan, Nadine Ahmed, Dennis Özcelik, John Paul Pezacki

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 34 citations in OpenAlex.

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  17. Repression ofFrontiers in endocrinology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tyler A ShawDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Canada.
Ragunath SingaraveluDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Canada.
Megan H PowdrillDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Canada.
Jordan NhanDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Canada.
Nadine AhmedDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Canada.
Dennis ÖzcelikDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Canada.
John Paul PezackiDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada. Electronic address: john.pezacki@uottawa.ca.
University of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are part of a complex regulatory network that modulates cellular lipid metabolism. Here, we identify miR-124 as a regulator of triglyceride (TG) metabolism. This study advances our knowledge of the role of miR-124 in human hepatoma cells. Transcriptional profiling of Huh7.5 cells overexpressing miR-124 reveals enrichment for host factors involved in fatty acid oxidation among repressed miRNA targets. In addition, miR-124 down-regulates arylacetamide deacetylase (AADAC) and adipose triglyceride lipase, lipases proposed to mediate breakdown of hepatic TG stores for lipoprotein assembly and mitochondrial β-oxidation. Consistent with the inhibition of TG and fatty acid catabolism, miR-124 expression promotes cellular TG accumulation. Interestingly, miR-124 inhibits the production of hepatitis C virus, a virus that hijacks lipid pathways during its life cycle. Antiviral activity of miR-124 is consistent with repression of AADAC, a pro-viral host factor. Overall, our data highlight miR-124 as a novel regulator of TG metabolism in human hepatoma cells.

Indexed as

Biochemical MechanismBiochemistryBiological Sciences

Identifiers

PMID30528902
PMCPMC6282456
OpenAlexW2901951586

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.