Evidence map›Paper›PMID 30528879›Full record

ArticleNeuroscience letters2019

Muscular effort increases hand-blink reflex magnitude.

R J Bufacchi, S Ponticelli, G Novembre, M Kilintari, Y Guo, G D Iannetti

Abstract read
In one paragraph

Article in Neuroscience letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. The blink reflex and its modulation - Part 1: Physiological mechanisms.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

R J BufacchiDepartment of Neuroscience, Physiology and Pharmacology, University College London (UCL), London, UK; Centre for Mathematics and Physics in the Life Sciences and EXperimental biology (CoMPLEX), University College London, London, UK.
S PonticelliDepartment of Neuroscience, Physiology and Pharmacology, University College London (UCL), London, UK.
G NovembreNeuroscience and Behaviour Laboratory, Istituto Italiano di Tecnologia, Rome, Italy.
M KilintariDepartment of Neuroscience, Physiology and Pharmacology, University College London (UCL), London, UK.
Y GuoDepartment of Neuroscience, Physiology and Pharmacology, University College London (UCL), London, UK.
G D IannettiDepartment of Neuroscience, Physiology and Pharmacology, University College London (UCL), London, UK; Neuroscience and Behaviour Laboratory, Istituto Italiano di Tecnologia, Rome, Italy. Electronic address: g.iannetti@ucl.ac.uk.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Defensive motor responses elicited by sudden environmental stimuli are finely modulated by their behavioural relevance to maximise the organism's survival. One such response, the blink reflex evoked by intense electrical stimulation of the median nerve (Hand-Blink Reflex; HBR), has been extensively used to derive fine-grained maps of defensive peripersonal space. However, as other subcortical reflexes, the HBR might also be modulated by lower-level factors that do not bear direct relevance to the defensive value of blinking, thus posing methodological and interpretive problems. Here, we tested whether HBR magnitude is affected by the muscular effort present when holding the hand in certain postures. We found that HBR magnitude increases with muscular effort, an effect most likely mediated by the increased corticospinal drive. However, we found strong evidence that this effect is substantially smaller than the well-known effect of eye-hand proximity on HBR magnitude. Nonetheless, care should be taken in future experiments to avoid erroneous interpretations of the effects of muscular effort as indicators of behaviour relevance.

Indexed as

BlinkingReflexAdultElectric StimulationFemaleHandHumansMaleMedian NerveMuscle, SkeletalPostureYoung AdultBlink reflexDefenceMotor systemMuscular effortThreat

Identifiers

PMID30528879
PMCPMC6527920

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.