Observational studyThe Journal of pediatrics2019
Exposure to Diabetes in Utero Is Associated with Earlier Pubertal Timing and Faster Pubertal Growth in the Offspring: The EPOCH Study.
Observational study in The Journal of pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pubertal timing in boys and girls born to mothers with gestational diabetes mellitus: a systematic review.European journal of endocrinology · 2021Pooled it
- Article
- The Impact of Gestational Diabetes Mellitus on Minipuberty in Girls.International journal of molecular sciences · 2024Article
- Epigenetic age acceleration is associated with speed of pubertal growth but not age of pubertal onset.Scientific reports · 2024Article
- Gestational diabetes mellitus and linear growth in early childhood.Frontiers in endocrinology · 2024Article
- Exposure to Gestational Diabetes and BMI Trajectories Through Adolescence: The Exploring Perinatal Outcomes Among Children Study.The Journal of clinical endocrinology and metabolism · 2023Article
- Sex differences in glycolipidic disorders after exposure to maternal hyperglycemia during early development.Journal of endocrinological investigation · 2023Review
- Power and sample size analysis for longitudinal mixed models of health in populations exposed to environmental contaminants: a tutorial.BMC medical research methodology · 2023Review
- Hyperglycemia in Pregnancy and Women's Health in the 21st Century.International journal of environmental research and public health · 2022Review
- Gestational diabetes mellitus, epigenetic age and offspring metabolism.Diabetic medicine : a journal of the British Diabetic Association · 2022Article
- Genetic Interactions with Intrauterine Diabetes Exposure in Relation to Obesity: The EPOCH and Project Viva Studies.Pediatric reports · 2021Article
- Prenatal exposure to mercury and precocious puberty: a prospective birth cohort study.Human reproduction (Oxford, England) · 2021Article
- Using the SITAR Method to Estimate Age at Peak Height Velocity of Children in Rural South Africa: Ellisras Longitudinal Study.Children (Basel, Switzerland) · 2020Article
- A prospective study of associations between in utero exposure to gestational diabetes mellitus and metabolomic profiles during late childhood and adolescence.Diabetologia · 2020Article
- Parental Obesity and Offspring Pubertal Development: Project Viva.The Journal of pediatrics · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo examine the associations of in utero exposure to maternal diabetes with surrogate measures of offspring pubertal timing (age at peak height velocity [APHV]) and speed of pubertal growth (peak height velocity [PHV]). STUDY
designData from 77 exposed and 340 unexposed youth followed from age 2 to 19 years (51% non-Hispanic white, 50% female) were analyzed using the Exploring Perinatal Outcomes among Children study, a historical prospective cohort. Maternal diabetes status was collected from obstetric records, and child heights from 2 years to current age from pediatric records. Other covariates were collected during research visits. The superimposition by translation and rotation method, using height measurements (4-52 per participant), modeled APHV and PHV. Accelerated failure time analyses were used to test whether exposure to maternal diabetes was associated with younger APHV and faster PHV.
resultsAdjusting for child's sex, race/ethnicity, and socioeconomic status, median APHV was reached ~3 months earlier in youth exposed to maternal diabetes compared with unexposed youth (P < .03). Youth exposed to maternal diabetes had a faster PHV than unexposed youth: exposed girls had 10.5% greater median PHV compared with unexposed girls and exposed boys had a 4.0% greater median PHV compared with unexposed boys (P < .001 for exposure by sex interaction).
conclusionsOur findings provide evidence that exposure to maternal diabetes in utero is associated with earlier pubertal timing and faster pubertal growth. Whether earlier puberty or faster speed of pubertal growth mediates the association between maternal diabetes exposure and later chronic disease risk remains to be studied.
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